Bruce, S. O.; Nwafor, O. I.; Omoirri, M. A.; Adione, N. M.; Onyeka, I. P.; Ezeoru, V. C. published the artcile< GC-MS, FTIR and antiulcer screening of aqueous seed extract and oil of Nigella sativa in wistar rats>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Nigella seed extract antiulcer agent phytochem peptic ulcer.
Peptic ulcer disease (PUD) is a sore in the lining of the stomach or duodenal mucosa. This study was aimed at evaluating the antiulcer activity of the aqueous extract of Nigella sativa (black seed) and its constitutents. The pharmacognostic properties of the dry seeds were determined The seeds were extracted using two methods digestion and hydro-distillation The acute toxicity, phytochem. constituents and the antiulcer evaluation were performed on ethanol-induced ulcer in wistar rats using a standard method. FTIR and GC-MS anal. of the aqueous seed extract was also determined using standard methods. Nigella sativa seed shows the presence of starch grains, lignified tissues, tannins, cellulose, protein and oil globules. The aqueous extract has a high safety margin. The phytochem. studies revealed the presence of saponins, flavonoids, alkaloids, tannins, glycosides, fats and oil. The black seed aqueous and oil extract at 500 mg/kg significantly reduced the acidity, total acidity, and ulcer index, and pH of gastric content when compared with the pos. control (Famotidine). The FTIR anal. identified the presence of the following functional groups chloro, ether, amine, carboxylic acid, nitriles, methylene, alc., while the GC-MS identified five compounds such as glycerin, n-Hexadecanoic acid, 9, 12-octadecadienoic acid-Me ester, 9, 12-octadecadienoic acid and 9, 12-octadecadienoyl chloride. The pharmacognostic properties can act as a reliable tool for the standardization of the plant part. This study suggests that aqueous and oil extract possess antiulcer properties. Thus the aqueous and oil extract of black seed can be considered as antiulcer medication traditionally.
Journal of Drug Delivery and Therapeutics published new progress about Alkaloids Role: PAC (Pharmacological Activity), THU (Therapeutic Use), BIOL (Biological Study), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
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