Doebelin, Christelle; Patouret, Remi; Garcia-Ordonez, Ruben D.; Chang, Mi Ra; Dharmarajan, Venkatasubramanian; Novick, Scott; Ciesla, Anthony; Campbell, Sean; Solt, Laura A.; Griffin, Patrick R.; Kamenecka, Theodore M. published the artcile< Identification of potent RORβ modulators: Scaffold variation>, Application In Synthesis of 112-63-0, the main research area is aminothiophene preparation retinoid related orphan receptor RORbeta modulator; Aminothiophene; Nuclear receptor; RORβ; Selective ligand.
The authors sought to develop RORβ-selective probe mols. to investigate the function of the receptor in vitro and in vivo and its role in the pathophysiol. of disease. To accomplish this, the authors modified a potent dual RORβ/RORγ inverse agonist from the primary literature with the goal of improving selectivity for RORβ vs. RORγ. Truncation of the Western portion of the mol. ablated activity at RORγ and led to a potent series of RORβ modulators. Continued exploration of this series investigated alternate replacement cores for the aminothiazole ring. Numerous suitable replacements were found during the course of the authors’ SAR investigations and are reported herein.
Bioorganic & Medicinal Chemistry Letters published new progress about Acylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics