Feng, Yin-Hsun; Lim, Sher-Wei; Lin, Hong-Yi; Wang, Shao-An; Hsu, Sung-Po; Kao, Tzu-Jen; Ko, Chiung-Yuan; Hsu, Tsung-I. published the artcile< Allopregnanolone suppresses glioblastoma survival through decreasing DPYSL3 and S100A11 expression>, Quality Control of 112-63-0, the main research area is glioblastoma cell survival DPYSL3 S100A11 allopregnanolone; Allopregnanolone; Glioblastoma; iTRAQ.
Allopregnanolone (allo) is a physiol. regulator of neuronal activity that treats multiple neurol. disorders. Allo penetrates the blood-brain barrier with very high efficiency, implying that allo can treat CNS-related diseases, including glioblastoma (GBM), which always recurs after standard therapy. Hence, this study aimed to determine whether allo has a therapeutic effect on GBM. We found that allo enhanced temozolomide (TMZ)-suppressed cell survival and proliferation of TMZ-resistant cells. In particular, allo enhanced TMZ-inhibited cell migration and TMZ-induced apoptosis. Addnl., allo strongly induced DNA damage characterized by γH2Ax. Furthermore, quant. proteomic anal., iTRAQ, showed that allo significantly decreased the levels of DPYSL3, S100A11, and S100A4, reflecting the poor prognosis of patients with GBM confirmed by differential gene expression and survival anal. Moreover, single-cell RNA-Seq revealed that S100A11, expressed in malignant cells, oligodendrocytes, and macrophages, was significantly associated with immune cell infiltration. Furthermore, overexpression of DPYSL3 or S100A11 prevented allo-induced cell death. In conclusion, allo suppresses GBM cell survival by decreasing DPYSL3/S100A11 expression and inducing DNA damage.
Journal of Steroid Biochemistry and Molecular Biology published new progress about Albumins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.
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