Wang, Shaohui; Jiang, Yao; Liu, Yabo; Liu, Qianhui; Sun, Hongwei; Mei, Mengjie; Liao, Xiaomei published the artcile< Ferroptosis promotes microtubule-associated protein tau aggregation via GSK-3β activation and proteasome inhibition>, Product Details of C15H22N2O2, the main research area is neuroblastoma cell ferroptosis microtubule tau aggregation GSK3b proteasome; Ferroptosis; Glycogen synthase kinase-3β; Tau; Ubiquitin proteasome system.
Ferroptosis is a form of regulated cell death resulting from iron accumulation and lipid peroxidation Iron dyshomeostasis and peroxidation damage of neurons in some particular brain regions are closely related to a wide range of neurodegenerative diseases known as “”tauopathies,”” in which intracellular aggregation of microtubule-associated protein tau is the common neuropathol. feature. However, the relationship between ferroptosis and tau aggregation is not well understood. The current study demonstrates that erastin-induced ferroptosis can promote tau hyperphosphorylation and aggregation in mouse neuroblastoma cells (N2a cells). Moreover, ferroptosis inhibitor ferrostatin-1 can alleviate tau aggregation effectively. In-depth mechanism research indicates that activated glycogen synthase kinase-3β (GSK-3β) is responsible for the abnormal hyperphosphorylation of tau. More importantly, proteasome inhibition can exacerbate tau degradation obstacle and accelerate tau aggregation in the process of ferroptosis. Our results indicate that ferroptosis can lead to abnormal aggregation of tau protein and might be a promising therapeutic target of tauopathies.
Molecular Neurobiology published new progress about Autophagy. 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Product Details of C15H22N2O2.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics