Liu, Yue; Zhang, Ying; Huang, Qian-Wei; Gou, Chuan; Li, Qing-Zhu; Dai, Qing-Song; Leng, Hai-Jun; Li, Jun-Long published the artcile< Organocatalytic Enantioselective Synthesis of Tetrahydro-Furanyl Spirooxindoles via [3+2] Annulations of 3-Hydroxyoxindoles and Cyclic Ketolactams>, HPLC of Formula: 112-63-0, the main research area is hydoxyindole pyrrolidinedione cinchona catalyst enantioselective antitumor cyclization; tetrahydrofuranyl spirooxindole preparation.
Asym. construction of pharmacol. interesting tetrahydrofuranyl spirooxindole frameworks was achieved through organocatalytic [3+2] annulations of the readily available 3-hydroxyoxindoles and pyrrolidone-derived cyclic ketolactams. A variety of chiral spiro tetrahydrofuranyl products, which contained four contiguous stereocenters including two tetrasubstituted carbon centers were rapidly synthesized with remarkable results (up to 99% yield, >95:5 dr and 99:1 er). Synthetic derivatization of the hemiketal moiety enabled the installation of various halogen atoms into the structurally complex mols. in a stereospecific manner. Preliminary screening of anticancer bioactivity was performed, and 4 w showed obvious inhibitory capacity to the proliferation on a panel of cancer cell lines.
Advanced Synthesis & Catalysis published new progress about [3+2] Cycloaddition reaction catalysts (stereoselective). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics