Yokota, Chisato; Kagawa, Naoki; Takano, Koji; Chiba, Yasuyoshi; Kinoshita, Manabu; Kijima, Noriyuki; Oji, Yusuke; Oka, Yoshihiro; Sugiyama, Haruo; Tsuboi, Akihiro; Izumoto, Shuichi; Kishima, Haruhiko; Hashimoto, Naoya published the artcile< Maintenance of WT1 expression in tumor cells is associated with a good prognosis in malignant glioma patients treated with WT1 peptide vaccine immunotherapy>, HPLC of Formula: 112-63-0, the main research area is CD4 CD8 WT1 malignant glioma peptide vaccine immunotherapy; Cancer vaccine; Glioma; Immunotherapy; Intra-tumor immune response; Wilms tumor gene 1.
We have previously revealed the overexpression of Wilms’ tumor gene 1 (WT1) in malignant glioma and developed WT1 peptide vaccine cancer immunotherapy. A phase II clin. trial indicated the clin. efficacy of the WT1 peptide vaccine for recurrent malignant glioma. Here, we aimed to investigate the immunol. microenvironment in glioma tissues before and after WT1 peptide vaccine treatment. Paired tissue samples were obtained from 20 malignant glioma patients who had received the WT1 peptide vaccine for > 3 mo and experienced tumor progression, confirmed radiog. and/or clin., during vaccination. We discovered that the expression of WT1 and HLA class I antigens in the tumor cells significantly decreased after vaccination. Maintenance of WT1 expression, which is the target mol. of immunotherapy, in tumor cells during the vaccination period was significantly associated with a longer progression-free and overall survival. A high expression of HLA class I antigens and low CD4+/CD8+ tumor-infiltrating lymphocytes (TIL) ratio in pre-vaccination specimens, were also associated with a good prognosis. No statistically significant difference existed in the number of infiltrating CD3+ or CD8+ T cells between the pre- and post-vaccination specimens, whereas the number of infiltrating CD4+ T cells significantly decreased in the post-vaccination specimens. This study provides insight into the mechanisms of intra-tumoral immune reaction/escape during WT1 peptide vaccine treatment and suggests potential clin. strategies for cancer immunotherapy.
Cancer Immunology Immunotherapy published new progress about Cancer immunotherapy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.
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