Yang, Guo-Hui; Zheng, Hanliang; Li, Xin; Cheng, Jin-Pei published the artcile< Asymmetric Synthesis of Axially Chiral Phosphamides via Atroposelective N-Allylic Alkylation>, Application In Synthesis of 112-63-0, the main research area is atroposelective allylic alkylation MBH carbonate phosphamide; axially chiral phosphamide preparation crystal structure; mol structure axially chiral phosphamide; linear free energy relationship axially chiral phosphamide.
Axially chiral anilide compounds are an emerging but scarcely studied class of stereogenic mols. with potential applications as biol. active scaffolds. Because of the lower rotation barriers, the synthesis of these compounds is a challenging task. Also, the status of the limited structure type of chiral anilide constrains the latent capacity of the C-N axis as a chiral source in the application of asym. synthesis. Herein, the authors disclose an efficient protocol for the construction of the rationally designed axially chiral phosphamides via atroposelective N-allylic alkylation reaction of MBH carbonates and phosphamides. The simple hydroquinidine catalyst proves to be most efficient in this artroposelective strategy, delivering the desired axially chiral phosphamides in good yields and high enantioselectivities. A phosphamide compound, which contains both P-stereogenic center and C-N axial chirality, can be obtained by this method through a kinetic resolution process. Because of the large steric diaryl phosphoryl group, the synthesized axially chiral anilide has a large rotational barrier. As a demonstration, current studied axially chiral ortho-I substituted phosphamides could act as efficient chiral hypervalent I(III) catalysts for the asym. oxidative dearomatization of phenols. Also, a speculative model, which can explain the enantiocontrol, is proposed based on the exptl. observation and theor. calculation
ACS Catalysis published new progress about Alkylation catalysts (chiral sulfonamides). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics