Ziemczonek, Piotr; Gosecka, Monika; Gosecki, Mateusz; Marcinkowska, Monika; Janaszewska, Anna; Klajnert-Maculewicz, Barbara published the artcile< Star-Shaped Poly(furfuryl glycidyl ether)-Block-Poly(glyceryl glycerol ether) as an Efficient Agent for the Enhancement of Nifuratel Solubility and for the Formation of Injectable and Self-Healable Hydrogel Platforms for the Gynaecological Therapies>, HPLC of Formula: 112-63-0, the main research area is PFGE block PGGE hydrogel nifuratel solubility gynaecol therapy; Trichomonas infections; candidiasis; drug delivery system; hydrophobic drug; nifuratel; poly(furfuryl glycidyl ether); poly(glyceryl glycerol ether); unimolecular copolymer micelle; vulvovaginitis.
In this paper, we present novel well-defined unimol. micelles constructed a on poly(furfuryl glycidyl ether) core and highly hydrophilic poly(glyceryl glycerol ether) shell, PFGE-b-PGGE. The copolymer was synthesized via anionic ring-opening polymerization of furfuryl glycidyl ether and (1,2-isopropylidene glyceryl) glycidyl ether, resp. MTT assay revealed that the copolymer is non-cytotoxic against human cervical cancer endothelial (HeLa) cells. The copolymer thanks to furan moieties in its core is capable of encapsulation of nifuratel, a hydrophobic nitrofuran derivative, which is a drug applied in the gynaecol. therapies that shows a broad antimicroorganism spectrum. The study shows high loading capacity of the copolymer, i.e., 146 mg of nifuratel per 1 g of copolymer. The load unimol. micelles were characterized using DLS and TEM microscopy and compared with the reference glyceryl glycerol ether homopolymer sample. The presence of numerous 1,2-diol moieties in the shell of PFGE-b-PGG macromols. enabled the formation of reversible crosslinks with 2-acrylamidephenylboronic acid-based polyacrylamide. The obtained hydrogels were both injectable and self-healable, which was confirmed with a rheol. study.
International Journal of Molecular Sciences published new progress about Anionic ring-opening polymerization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics