Wong, Thomas Y.; Zhang, Kevin S.; Gandhi, Ripal T.; Collins, Zachary S.; O’Hara, Ryan; Wang, Eric A.; Vaheesan, Kirubahara; Matsuoka, Lea; Sze, Daniel Y.; Kennedy, Andrew S.; Brown, Daniel B. published the artcile< Long-term outcomes following 90Y Radioembolization of neuroendocrine liver metastases: evaluation of the radiation-emitting SIR-spheres in non-resectable liver tumor (RESiN) registry>, Reference of 112-63-0, the main research area is yttrium90 radiation therapy prognosis neuroendocrine tumor hepatotoxicity liver metastasis; Liver cancer; Metastases; Neuroendocrine tumor.
The goal of this study was to evaluate efficacy and safety of 90Y radioembolization for neuroendocrine liver metastases (NELM) in a multicenter registry. One hundred-seventy patients with NELM were enrolled in the registry (NCT 02685631). Prior treatments included hepatic resection (n = 23, 14%), arterial therapy (n = 62, 36%), octreotide (n = 119, 83%), cytotoxic chemotherapy (n = 58, 41%), biol. therapy (n = 49, 33%) and immunotherapy (n = 10, 6%). Seventy-seven (45%) patients had extrahepatic disease. Seventy-eight (48%), 61 (37%), and 25 (15%) patients were Eastern Cooperative Oncol. Group (ECOG) performance status of 0, 1, or ≥ 2. Tumor grade was known in 81 (48%) patients: 57 (70%) were well-, 12 (15%) moderate-, and 12 (15%) poorly-differentiated. Kaplan-Meier anal. and log rank tests were performed to compare overall and progression-free survival (OS/PFS) by tumor location and grade. Toxicities were reported using Common Terminol. Criteria for Adverse Events v.5. Cox Proportional Hazards were calculated for pancreatic primary, performance status, extrahepatic disease at treatment, unilobar treatment, baseline ascites, and > 25% tumor burden. One, 2, and 3-yr OS rates were 75, 62 and 46%, resp. Median OS was 33 mo 95% CI: 25-not reached. The longest median OS was in patients with pancreatic (42 mo, 95% CI: 33-NR) and hindgut (41 mo, 95% CI: 12-NR) primaries. The shortest OS was in foregut primaries (26 mo; 95% CI: 23-NR; X2 = 7, p = 0.1). Median OS of well-differentiated tumors was 36 mo (95% CI: 10-NR), compared to 44 (95% CI: 7-NR) and 25 (95% CI: 3-NR) months for moderate and poorly differentiated tumors. Median progression-free survival (PFS) was 25 mo with 1, 2, and 3-yr PFS rates of 70, 54, and 35%, resp. Thirteen patients (7.6%) developed grade 3 hepatic toxicity, most commonly new ascites (n = 8, 5%) at a median of 5.5 mo. Performance status of ≥2 (HR 2.7, p = 0.01) and baseline ascites (HR 2.8, P = 0.049) predicted shorter OS. Discussion: In a population with a high incidence of extrahepatic disease, 90Y was effective and safe in treatment of NELM, with median OS of 41 mo for well differentiated tumors. Grade 3 or greater hepatic toxicity was developed in 7.6% of patients. Trial registration: NCT 02685631.
BMC Cancer published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.
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