The author of 《Optimisation and validation of a GC-MS/MS method for the analysis of methyl salicylate in hair and skin samples for use in human-volunteer decontamination studies》 were James, Thomas; Collins, Samuel; Amlot, Richard; Marczylo, Tim. And the article was published in Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences in 2019. Computed Properties of C8H8O3 The author mentioned the following in the article:
Me salicylate has a long history of use as a chem. warfare agent simulant for volatile lipophilic compounds such as sulfur mustard. An improved isotope dilution GC-MS/MS method was developed, optimized and validated for the anal. of Me salicylate in human skin and hair samples, for use in emergency decontamination volunteer studies. Following derivatization, quantification was measured on a triple quadrupole mass spectrometer, set to EI mode and conducting multiple reaction monitoring of target ions. The mass transitions were 209→179 and 213→161 for quantitation of Me salicylate and Me salicylate D4, resp. whereas qualifier ion transitions used to verify identity were 209→169 and 213→89. The method achieved excellent coefficient of determination (R2 >0.9968 to 0.9999) over the range of 0.5-5000 ng/mL and the LOD and LOQ were 0.05 ng/mL and 0.5 ng/mL. The method was further validated for accuracy (intra-day and inter-day average 100.28% to 102.03% and 99.48% to 102.33%, resp.) and precision (intra-day RSD 1.43% to 2.35%, inter-day RSD 1.91% to 2.97%) at three concentrations (25, 250 and 2500 ng/mL). The validated method was successfully used to identify Me salicylate in samples of human skin generated during volunteer studies of emergency decontamination systems and in hair of staff conducting these studies.Methyl Salicylate(cas: 119-36-8Computed Properties of C8H8O3) was used in this study.
Methyl Salicylate(cas: 119-36-8) is a natural herbivore-induced plant volatile. It is a naturally occurring product in trees, legumes, exotic plants, vegetables, berries, and the primary constituent of the oil of wintergreen.Methyl Salicylate is produced from salicylic acid.Computed Properties of C8H8O3
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