Alcaro, S.; Arena, A.; Neri, S.; Ottana, R.; Ortuso, F.; Pavone, B.; Vigorita, M. G. published the artcile< Design and synthesis of DNA-intercalating 9-fluoren-β-O-glycosides as potential IFN-inducers, and antiviral and cytostatic agents>, Product Details of C19H34O2, the main research area is anthracycline glycoside antiviral herpesvirus antitumor drug design.
Novel 9-fluoren-β-O-glycosides, designed as DNA-intercalating agents in structural correlation with antiviral tilorone and anticancer anthracyclines, have been prepared with yields in β-anomers ranging between 25 and 63%. They have been screened for antiproliferative, immunostimulating and antiviral properties against HSV-1 and HSV-2 viruses. Compounds displaying significant antiviral activity against HSV-2 are acetylated (1) and deprotected (6) 9-fluorenyl-O-d-arabinopyranoses, whereas 9-fluorenyl-O-d-glucopyranose (pharmacokinetics, efficacy, and safety) is the most effective on HSV-1 replication, followed by 1 and 6. The conformational properties of these compounds have been evaluated by mol. modeling techniques.
Bioorganic & Medicinal Chemistry published new progress about Anthracycline glycosides Role: PAC (Pharmacological Activity), PRP (Properties), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), PREP (Preparation), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.
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