Jang, Keun Sam; Shin, Dong Seok; Srisook, Ekaruth; Song, Ho-Chun; Chi, Dae Yoon published the artcile< Versatile functionalization of electron rich-fused heterocyclic arenes via electrophilic aromatic addition reaction and their applications>, SDS of cas: 112-63-0, the main research area is methoxyquinaldine regioselective bromomethoxylation; bromo alkoxyquinaldine preparation; dibromo dimethoxydihydroquinaldine amine regioselective nucleophilic substitution reaction; amino bromo methoxyyquinaldine preparation.
Divergent functionalized 8-methoxyquinaldines were synthesized via regioselective debromination, 1,3-bromine shift process, aromatization with treatment of a strong base, nucleophilic substitution reaction at the C7 position using amines and cyanide as a nucleophile in the absence of a metal source and a catalyst from an unusual electrophilic aromatic addition (AdEAr) reaction products. In addition, quinaldine-7,8-dione was prepared by presence of CAN (ceric ammonium nitrate) in AcOH and H2O for 10 min at room temperature from N-(alkylamino)-8-methoxyquinalidines. During the AdEAr reaction, new stereoselective dearomatized addition products were generated via discriminative reaction routes depending on the methoxy and bromine occupancy position. The AdEAr reaction not only allowed for the functionalization of electron rich-fused heterocyclic arenes, but also provided a new synthetic route to an alternative mechanism for electrophilic aromatic substitution reactions.
Tetrahedron published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics