Month: February 2023

Synthesis of new donor-acceptor copolymer and its application in organic bulk hetero-junction solar cells was written by Zou, Wenwu;Liu, Ying;Jia, Qingming;Ge, Ziyi. And the article was included in Youji Huaxue in 2013.Category: esters-buliding-blocks This article mentions the following:

Alternative copolymer (PBDTDT) was synthesized from acceptor unit with strong electro-withdrawing structure of di-Bu malonate in branch chain and donor unit based on benzo[1,2-b:4,5-b’]dithiophene. And its thermal, optical, electrochem. properties and photovoltaic properties blending with [6,6]-phenyl-C₇₁ butyric acid Me ester as the active layer in the bulk hetero-junction devices of organic solar cells were investigated. The influence of different ratio of polymer PBDTDT and PC₇₁BM on the photovoltaic properties was also studied. And the open voltage reached 0.82 V, when the weight ratio of PBDTDT and PC₇₁BM is 1 3, and its power conversion efficiency (PCE) was 0.90%, with V_oc of 0.82 V, J_sc of 3.25 mA/cm² and FF of 33.8%. Comparing with the poly(3-hexylthiophene) (P3HT) in the same method, the solar cells with P3HT blending with PC₇₁BM as the active layer can only get 0.55 V, which can be lower about 0.29 V than that of the PBDTDT. And the possible factors resulting in low PCE and the higher open voltage than that of P3HT were analyzed. In the experiment, the researchers used many compounds, for example, malonic acid dibutyl ester (cas: 1190-39-2Category: esters-buliding-blocks).

malonic acid dibutyl ester (cas: 1190-39-2) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Vanillin esters in reactions with indan-1,3-dione was written by Kozlov, N. G.;Basalaeva, L. I.. And the article was included in Chemistry of Heterocyclic Compounds (New York, NY, United States) in 2006.Recommanded Product: 4-Formyl-2-methoxyphenyl isobutyrate This article mentions the following:

2-Methoxy-4-(12-oxo-12H-benzo[f]indeno[1,2-b]quinolin-13-yl)phenyl esters of carboxylic acids were synthesized by the three-component condensation of indan-1,3-dione, 2-naphthylamine, and O-acylvanillin. 2-Arylideneindan-1,3-diones formed during the reaction were isolated. In the experiment, the researchers used many compounds, for example, 4-Formyl-2-methoxyphenyl isobutyrate (cas: 20665-85-4Recommanded Product: 4-Formyl-2-methoxyphenyl isobutyrate).

4-Formyl-2-methoxyphenyl isobutyrate (cas: 20665-85-4) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Recommanded Product: 4-Formyl-2-methoxyphenyl isobutyrate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Processability and physico-mechanical properties of ultrahigh-molecular-weight polyethylene using low-molecular-weight olefin wax was written by Bakshi, Ashok Kumar;Ghosh, Anup K.. And the article was included in Polymer Engineering & Science in 2022.Category: esters-buliding-blocks This article mentions the following:

The influence of mol. weight of olefin wax as a plasticizer on the processability and properties of ultrahigh-mol.-weight polyethylene (UHMWPE) was thoroughly investigated in this study. Two different grades of olefin wax (H5 and 210P) were used sep. to plasticize UHMWPE. Comparative results were analyzed based on mixing torque, mech., thermal, thermo-mech., and morphol. aspects. The Gaussian math. model was applied to the internal thermo-shear batch mixing torque data to predict processability and plasticization of the resulting compounds The relatively low-mol.-weight wax (H5) seemed to be more efficient at uncoiling the entanglements among the amorphous phase of UHMWPE. The lowest degree of crystallinity range (34%-40%) and the highest nucleation rate (0.9 min^-1) were found with 10 phr H5 wax plasticized UHMWPE. The tensile strength of 30.5 MPa and elastic modulus of 127 MPa, achieved by the addition of H5 wax at 10 phr loading, confirmed the optimum effect of plasticization. The plasticization effect was also established from the loss moduli and Cole-Cole plots. A smaller number of multiple stress-induced overshoots and the inclining approach toward the viscous dominant regime with temperature sweep were observed in the case of 10 phr H5 wax composition SEM anal. revealed disappearance of interfacial crazing and interparticle boundaries progressively with the increase in H5 wax content. Overall, plasticized UHMWPE with 10 phr content of H5 wax showed the optimum processability and properties. In the experiment, the researchers used many compounds, for example, 2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8Category: esters-buliding-blocks).

2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Preparation and Characterization of Polyoxymethlene/Thermoplastic Polyamide Elastomer Blends Compatibilized by Maleic Anhydride Grafted ABS Copolymer was written by Ruilong Li;Fang, Wei;Fan, Xiaodong;Jin, Zhengwei;Zhou, Tao. And the article was included in Polymer Science, Series A: Polymer Physics in 2021.Application of 6683-19-8 This article mentions the following:

Polyoxymethylene/thermoplastic polyamide elastomer composites were prepared by using maleic anhydride grafted acrylonitrile-butadiene-styrene copolymer as interfacial compatibilizer via melt extrusion. The compatibility and the properties of blends were studied by the mech. testing and various phys. chem. methods. The notched impact strength and elongation at break of blends were increased significantly after adding of compatibilizer. Simultaneously, the phase structure and crystal shape of the blends were changed. Finally, the elastomer particles were more uniform, and more amorphous regions were produced in the blends. In the experiment, the researchers used many compounds, for example, 2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8Application of 6683-19-8).

2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Application of 6683-19-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis and Investigation of Therapeutic Potential of Isoform-Specific HDAC8 Inhibitors for the Treatment of Cutaneous T Cell Lymphoma was written by Umamaheswari, Appavoo;Puratchikody, Ayarivan;Hari, Natarajan. And the article was included in Anti-Cancer Agents in Medicinal Chemistry in 2019.Recommanded Product: 106-79-6 This article mentions the following:

The aim of this paper was to synthesis and evaluates HDAC8 isoform specific inhibitors. Based on the preliminary report on the design and in-silico studies of 52 hydroxamic acid derivatives bearing multi-substituent heteroaromatic rings with chiral amine linker, five compounds were shortlisted and synthesized by microwave assisted approach and high yielding synthetic protocol. A series of in-vitro assays in addition to HDAC8 inhibitory activity was used to evaluate the synthesized compounds Serine derivatives I [R = H, MeO, OH; R¹ = H, Br; R² = Me, NH₂, MeO] and II exerted the anti-proliferative activities against CTCL cell lines at 20- 100 μM concentrations Both the compounds I and II exhibited μM inhibitory activity against HDAC8. The compound I [R = OH, R¹ = Br, R² = Me] displayed remarkable HDAC8 selectivity superior to that of the standard drug, SAHA with an IC50 at 0.1μM. Simple modifications at different portions of pharmacophore in the hydroxamic acid analogs were effective for improving both HDAC8 inhibitory activity and isoform selectivity. Potent and highly isoform-selective HDAC8 inhibitors were identified. These findings were expedient for further development of HDAC8-selective inhibitors. In the experiment, the researchers used many compounds, for example, Dimethyl decanedioate (cas: 106-79-6Recommanded Product: 106-79-6).

Dimethyl decanedioate (cas: 106-79-6) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Recommanded Product: 106-79-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mass spectrometry-based electronic nose to authenticate 100% Italian durum wheat pasta and characterization of volatile compounds was written by Cervellieri, Salvatore;Lippolis, Vincenzo;Mancini, Erminia;Pascale, Michelangelo;Logrieco, Antonio Francesco;De Girolamo, Annalisa. And the article was included in Food Chemistry in 2022.Product Details of 695-06-7 This article mentions the following:

Headspace solid-phase microextraction (HS-SPME) coupled with mass spectrometry-based electronic nose (MS-eNose), in combination with multivariate statistical anal. was used as untargeted method for the rapid authentication of 100% Italian durum wheat pasta. Among the tested classification models, i.e. PCA-LDA, PLS-DA and SVMc, SVMc provided the highest accuracy results in both calibration (90%) and validation (92%) processes. Potential markers discriminating pasta samples were identified by HS-SPME/GC-MS anal. Specifically, the content of a pattern of 8 out of 59 volatile organic compounds (VOCs) was significantly different between samples of 100% Italian durum wheat pasta and pasta produced with durum wheat of different origins, most of which were related to different lipidic oxidation in the two classes of pasta. The proposed MS-eNose method is a rapid and reliable tool to be used for authenticating Italian pasta useful to promote its typicity and preserving consumers from fraudulent practices. In the experiment, the researchers used many compounds, for example, 5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7Product Details of 695-06-7).

5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Product Details of 695-06-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Peptidomimetic vinyl heterocyclic inhibitors of cruzain effect antitrypanosomal activity was written by Chenna, Bala C.;Li, Linfeng;Mellott, Drake M.;Zhai, Xiang;Siqueira-Neto, Jair L.;Calvet Alvarez, Claudia;Bernatchez, Jean A.;Desormeaux, Emily;Alvarez Hernandez, Elizabeth;Gomez, Jana;McKerrow, James H.;Cruz-Reyes, Jorge;Meek, Thomas D.. And the article was included in Journal of Medicinal Chemistry in 2020.Application In Synthesis of (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate This article mentions the following:

Cruzain, an essential cysteine protease of the parasitic protozoan, Trypanosoma cruzi, is an important drug target for Chagas disease. We describe here a new series of reversible but time-dependent inhibitors of cruzain, composed of a dipeptide scaffold appended to vinyl heterocycles meant to provide replacements for the irreversible reactive “warheads” of vinyl sulfone inactivators of cruzain. Peptidomimetic vinyl heterocyclic inhibitors (PVHIs) containing Cbz-Phe-Phe/homoPhe scaffolds with vinyl-2-pyrimidine, vinyl-2-pyridine, and vinyl-2-(N-methyl)-pyridine groups conferred reversible, time-dependent inhibition of cruzain (K_i* = 0.1-0.4μM). These cruzain inhibitors exhibited moderate to excellent selectivity vs. human cathepsins B, L, and S and showed no apparent toxicity to human cells but were effective in cell cultures of Trypanosoma brucei brucei (EC₅₀ = 1-15μM) and eliminated T. cruzi in infected murine cardiomyoblasts (EC₅₀ = 5-8μM). PVHIs represent a new class of cruzain inhibitors that could progress to viable candidate compounds to treat Chagas disease and human sleeping sickness. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9Application In Synthesis of (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate).

(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Application In Synthesis of (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Identification and structure-activity relationship exploration of uracil-based benzoic acid and ester derivatives as novel dipeptidyl Peptidase-4 inhibitors for the treatment of type 2 diabetes mellitus was written by Li, Qing;Deng, Xiaoyan;Jiang, Neng;Meng, Liuwei;Xing, Junhao;Jiang, Weizhe;Xu, Yanjun. And the article was included in European Journal of Medicinal Chemistry in 2021.SDS of cas: 180636-50-4 This article mentions the following:

Our previously reported carboxyl-containing DPP-4 inhibitors were highly potent but were poorly bioavailable. Esters of the carboxyl analogs exhibited a significant DPP-4 potency loss albeit with enhanced oral absorption. Herein, we described identification and structure-activity relationship (SAR) exploration of a novel series of benzoic acid and ester derivatives as low single-digit nanomolar DPP-4 inhibitors. Importantly, the esters displayed comparable activities to the acids counterparts. Mol. simulation revealed that ester adopts a similar binding mode to acid. Moreover, the selected esters and acids demonstrated high selectivity and low cytotoxicity, as well as good metabolic stability. And more importantly, the esters possessed excellent pharmacokinetic profiles for oral administration. The best compound ester 19b demonstrated long DPP-4 inhibition in vivo, and robustly improved the glucose tolerance in normal and db/db mice while ensuring glucose-lowering potency in chronic treatment. Our results supported that the compound 19b can be served as a potential candidate for the treatment of type 2 diabetes. In the experiment, the researchers used many compounds, for example, Methyl 4-fluoro-3-methylbenzoate (cas: 180636-50-4SDS of cas: 180636-50-4).

Methyl 4-fluoro-3-methylbenzoate (cas: 180636-50-4) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.SDS of cas: 180636-50-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Copper(II) triflate catalyzed amination of 1,3-dicarbonyl compounds was written by Ton, Thi My Uyen;Himawan, Fanny;Chang, Joyce Wei Wei;Chan, Philip Wai Hong. And the article was included in Chemistry – A European Journal in 2012.Application of 13669-10-8 This article mentions the following:

Preparation of α,α-acyl amino acid derivatives was carried out efficiently by Cu(OTf)₂+1,10-phenanthroline (1,10-phen)-catalyzed amination of 1,3-dicarbonyl compounds with PhI=NSO₂Ar. The mechanism is thought to initially involve aziridination of the enolic form of the substrate, formed in situ through coordination to the Lewis acidic metal catalyst, by the putative copper-nitrene/imido species generated from the reaction of the metal catalyst with the iminoiodane source. Subsequent ring opening of the resultant aziridinol adduct under the Lewis acidic conditions then provided the α-aminated product. The utility of this method was exemplified by the enantioselective synthesis of a precursor of 3-styryl-2-benzoyl-L-alanine. © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Application of 13669-10-8).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Application of 13669-10-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

A Greener Route for Synthesis of Fly Ash Supported Heterogeneous Acid Catalyst was written by Malpani, Sakshi Kabra;Rani, Ashu. And the article was included in Materials Today: Proceedings in 2019.Synthetic Route of C9H10O3 This article mentions the following:

Fly ash, a solid byproduct obtained from coal-fired thermal power plants, is basically a silico-aluminate material having varying minor amounts of other metal oxides. For suitable bulk utilization of this solid waste, a novel kind of solid acid catalyst has been successfully synthesized by employing microwave assisted greener route. For enhancing the efficacy, amorphous silica was extracted from fly ash in a cost-effective manner which was further chem. activated with H₂SO₄. Various anal. techniques were utilized to study physico-chem. properties of the as-prepared catalyst, while the catalytic activity was tested by a serious of microwave assisted esterification and Friedel-Crafts alkylation reactions under optimized reaction conditions. Higher yield of products attributes to the presence of significant number of Bronsted acidic sites on catalyst, also proved by Pyridine adsorbed FT-IR spectrum of catalyst. The catalyst was recovered and reused up to five reaction cycles with similar competence as in first run which deliberates its stability during the course of reaction. In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxybenzoate (cas: 118-61-6Synthetic Route of C9H10O3).

Ethyl 2-hydroxybenzoate (cas: 118-61-6) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Synthetic Route of C9H10O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics