Month: February 2023

One-Pot Tandem Michael Addition/Enantioselective Conia-Ene Cyclization Mediated by Chiral Iron(III)/Silver(I) Cooperative Catalysis was written by Horibe, Takahiro;Sakakibara, Masato;Hiramatsu, Rin;Takeda, Kazuki;Ishihara, Kazuaki. And the article was included in Angewandte Chemie, International Edition in 2020.Reference of 13669-10-8 This article mentions the following:

The first one-pot tandem Michael addition/enantioselective Conia-ene cyclization of N-protected prop-2-yn-1-amines with 2-methylene-3-oxoalkanoates promoted by chiral iron(III)/silver(I) cooperative catalysts was developed. Alkyl 4-methylenepyrrolidine-3-acyl-3-carboxylates, which can be transformed into 灏?proline derivatives, were obtained in high yield with high enantioselectivity. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Reference of 13669-10-8).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Reference of 13669-10-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Optically active N- and C-terminal building blocks for the synthesis of peptidyl olefin peptidomimetics was written by Mirilashvili, Sima;Chasid-Rubinstein, Naama;Albeck, Amnon. And the article was included in European Journal of Organic Chemistry in 2010.Recommanded Product: 10203-58-4 This article mentions the following:

Peptidyl olefin peptidomimetics serve as biol. active compounds or as intermediates for other peptidyl isosteres. The N-terminal side of the C:C bond could be easily prepared in an optically pure form from 浼?amino acids. Synthesis of C-terminal building blocks in an optically pure form is more challenging. They include an electrophilic aldehyde and nucleophilic sulfone, phosphonium salt, phosphonate, and diselenide. Key enzymic hydrolysis of prochiral diesters to the corresponding hydroxy esters introduces optical activity. The sequence of the subsequent chem. reactions, either protection-hydrolysis-functionalization or functionalization-hydrolysis-protection, determines the absolute stereochem. of the final building blocks. In the experiment, the researchers used many compounds, for example, Diethyl isobutylmalonate (cas: 10203-58-4Recommanded Product: 10203-58-4).

Diethyl isobutylmalonate (cas: 10203-58-4) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Recommanded Product: 10203-58-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lewis Acid-Catalyzed Synthesis of Benzofurans and 4,5,6,7-Tetrahydrobenzofurans from Acrolein Dimer and 1,3-Dicarbonyl Compounds was written by Huang, Wenbo;Xu, Jing;Liu, Changhui;Chen, Zhiyan;Gu, Yanlong. And the article was included in Journal of Organic Chemistry in 2019.Recommanded Product: 13669-10-8 This article mentions the following:

2,3-Disubstituted benzofurans such as benzofurandicarboxylate I were prepared by cyclocondensation of acrolein dimer (2H-3,4-dihydro-2-pyrancarboxaldehyde) and 1,3-dicarbonyl compounds, particularly 灏?ketoesters and 1,3-diketones, in the presence of Lewis acid catalysts [either AlCl₃ or Sc(OTf)₃ or in one case, BF₃璺疎t₂O] using N-bromosuccinimide (NBS) as an oxidant. The method was used to prepare benzbromarone and amiodarone. An oxobutylfurancarboxylate intermediate in the cyclocondensation of acrolein dimer and Me acetoacetate was isolated; cyclocondensation with indoles, 1,2,4-trimethoxybenzene, and 1,1-diphenylethylene yielded aryl- and diphenylvinyl-substituted tetrahydrobenzofurancarboxylates such as II [R = 3-indolyl, 1-methyl-3-indolyl, 2,4,5-(MeO)₃C₆H₂, Ph₂C:CH]. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Recommanded Product: 13669-10-8).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Recommanded Product: 13669-10-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Key Odorants of Raw and Cooked Green Kohlrabi (Brassica oleracea var. gongylodes L.) was written by Marcinkowska, Monika;Frank, Stephanie;Steinhaus, Martin;Jelen, Henryk H.. And the article was included in Journal of Agricultural and Food Chemistry in 2021.Product Details of 695-06-7 This article mentions the following:

Volatile compounds of raw and cooked green kohlrabi were investigated using a sensomics approach. A total of 55 odor-active compounds were detected and identified in raw and cooked green kohlrabi using GC-O. Twenty-eight odor-active compounds with high flavor dilution (FD) factors ranging from 64 to 1024 were quantitated, and odor activity values (OAVs) were determined Eight compounds showed high OAVs in raw and cooked kohlrabi: five sulfur compounds (di-Me trisulfide, Me 2-methyl-3-furyl disulfide, and three isothiocyanates (1-isothiocyanato-3-(methylsulfanyl)propane, benzyl isothiocyanate, and 1-isothiocyanato-4-(methylsulfanyl)butane)), two lipid oxidation products (1-octen-3-one and trans-4,5-epoxy-(2E)-dec-2-enal), and 2-isopropyl-3-methoxypyrazine. Among these, the sulfur compounds contributed most to the overall smell of the raw and cooked vegetables. The quantitation anal. indicates that the eight odorants are the backbone compounds for raw and cooked kohlrabi. The OAVs for the backbone compounds and also for minor odorants are clearly higher in raw kohlrabi than in the cooked one. Differences can be explained by the influence of the cooking process. In the experiment, the researchers used many compounds, for example, 5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7Product Details of 695-06-7).

5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Product Details of 695-06-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

PAEs and PBDEs in plastic fragments and wetland sediments in Yangtze estuary was written by Deng, Hua;Li, Ruilong;Yan, Beizhan;Li, Bowen;Chen, Qiqing;Hu, Hui;Xu, Yong;Shi, Huahong. And the article was included in Journal of Hazardous Materials in 2021.Quality Control of Dicyclohexyl phthalate This article mentions the following:

Phthalates (PAEs) and polybrominated di-Ph ethers (PBDEs) are widely used as additives in various plastic products. Because of their ubiquity and potential hazards to the environment, they have attracted widespread attention. This research supports the addition critical data of the concentration and distribution of PAEs and PBDEs in the plastic fragments and wetland sediments in Yangtze Estuary. The concentrations of 鍗?PAEs and 鍗?PBDEs in the plastic samples in Yangtze Estuary wetlands were 26.8-4241.8娓璯/g and n.d. (no detectable) to 250.1娓璯/g, resp. The sixteen PAEs and eight PBDEs varied from 35.9 to 36225.2 ng/g and 3.9-253.0 ng/g in sediment samples. The dominant types of these chems. in plastic and sediment samples were diisobutyl phthalate (DIBP), di-Bu phthalate (DBP), dioctyl phthalate (DEHP) and BDE-209. According to correlation anal. and principal component anal., the major sources of additives in sediment were associated with the leak from plastic fragment and microplastic. Based on the equilibrium partitioning theory and Sediment Quality Guidelines (SeQGs), the ecol. risk of PAEs (high risk) and PBDEs (moderate risk) were evaluated. Overall, the investigated area has been moderately polluted by additives and microplastics; therefore, it is necessary to strengthen the control of environmental input of plastic waste. In the experiment, the researchers used many compounds, for example, Dicyclohexyl phthalate (cas: 84-61-7Quality Control of Dicyclohexyl phthalate).

Dicyclohexyl phthalate (cas: 84-61-7) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Quality Control of Dicyclohexyl phthalate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ruthenium-catalyzed benzylic substitution of benzyl esters with stabilized carbon nucleophiles was written by Suzuki, Koki;Tsuji, Hiroaki;Kawatsura, Motoi. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020.Recommanded Product: Diethyl isobutylmalonate This article mentions the following:

A [Cp*RuCl₂]₂/picolinic acid catalyst system promoted the reaction of 2-naphthylmethyl-2,3,4,5,6-pentafluorobenzoates with a series of stabilized carbon nucleophiles such as malonates, 灏?ketoesters, and diketones to give the corresponding benzylic alkylation products in moderate to high yields. A plausible reaction mechanism that could involve a (锜?benzyl)ruthenium intermediate is proposed. In the experiment, the researchers used many compounds, for example, Diethyl isobutylmalonate (cas: 10203-58-4Recommanded Product: Diethyl isobutylmalonate).

Diethyl isobutylmalonate (cas: 10203-58-4) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Recommanded Product: Diethyl isobutylmalonate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Recognition of the DNA minor groove by pyrrole-imidazole polyamides: comparison of desmethyl- and N-methylpyrrole was written by Bremer, R. E.;Szewczyk, J. W.;Baird, E. E.;Dervan, P. B.. And the article was included in Bioorganic & Medicinal Chemistry in 2000.HPLC of Formula: 5930-92-7 This article mentions the following:

Polyamides consisting of N-methylpyrrole (Py), N-methylimidazole (Im), and N-methyl-3-hydroxypyrrole (Hp) are synthetic ligands that recognize predetermined DNA sequences with affinities and specificities comparable to many DNA-binding proteins. As derivatives of the natural products distamycin and netropsin, Py/Im/Hp polyamides have retained the N-Me substituent, although structural studies of polyamide:DNA complexes have not revealed an obvious function for the N-Me. In order to assess the role of the N-Me moiety in polyamide:DNA recognition, a new monomer, desmethylpyrrole (Ds), where the N-Me moiety has been replaced with hydrogen, was incorporated into an eight-ring hairpin polyamide by solid-phase synthesis. MPE footprinting, affinity cleavage, and quant. DNase I footprinting revealed that replacement of each Py residue with Ds resulted in identical binding site size and orientation and similar binding affinity for the six-base-pair (bp) target DNA sequence. Remarkably, the Ds-containing polyamide exhibited an 8-fold loss in specificity for the match site vs. a mismatched DNA site, relative to the all-Py parent. Polyamides with Ds exhibit increased water solubility, which may alter the cell membrane permeability properties of the polyamide. The addition of Ds to the repertoire of available monomers may prove useful as polyamides are applied to gene regulation in vivo. However, the benefits of Ds incorporation must be balanced with a potential loss in specificity. In the experiment, the researchers used many compounds, for example, Ethyl 4-nitro-1H-pyrrole-2-carboxylate (cas: 5930-92-7HPLC of Formula: 5930-92-7).

Ethyl 4-nitro-1H-pyrrole-2-carboxylate (cas: 5930-92-7) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.HPLC of Formula: 5930-92-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

N-Benzylpiperidinol derivatives as novel USP7 inhibitors: structure-activity relationships and X-ray crystallographic studies was written by Li, Minglei;Liu, Shengjie;Chen, Hui;Zhou, Xinyu;Zhou, Jin;Zhou, Shuxi;Yuan, Haoliang;Xu, Qing-Long;Liu, Jun;Cheng, Keguang;Sun, Hongbin;Wang, Yue;Chen, Caiping;Wen, Xiaoan. And the article was included in European Journal of Medicinal Chemistry in 2020.Safety of tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzylcarbamate This article mentions the following:

Piperidinol derivatives I (R¹ = 4-FC₆H₄; R² = PhCH₂, 2-pyridyl, 2-thiazolyl, etc.) and II (R³ = Br, 4-H₂NCH₂C₆H₄, 4-AcNHCH₂C₆H₄CH₂, 4-BocNHCH₂C₆H₄; R⁴ = 2-Cl-4-MeO₂CC₆H₃CH₂) were designed, synthesized and biol. evaluated, and the compound II [R³ = 4-H₂NCH₂C₆H₄; R⁴ = 2-Cl-4-MeO₂CC₆H₃CH₂; (III)] was identified as a highly selective and potent USP7 inhibitor (IC₅₀ = 40.8 nM, K_D = 78.3 nM). X-Ray crystallog. studies revealed that the compound III bound to USP7 with a new pose that was very different than the previously reported inhibitors. The results of cellular assays showed that the compound III had strong antitumor activity against LNCaP (IC₅₀ = 29.6 nM) and RS4; 11 (IC₅₀ = 41.6 nM) cells, probably through inducing cell death and restricting G0/G1 and S phases. Moreover, III dose-dependently reduced the protein levels of MDM2 and DNMT1 and increased the protein levels of p53 and p21. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzylcarbamate (cas: 330794-35-9Safety of tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzylcarbamate).

tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzylcarbamate (cas: 330794-35-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Safety of tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzylcarbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Vanillin esters of aliphatic acids in the synthesis of 4,7-phenanthroline derivatives was written by Kozlov, N. G.;Gusak, K. N.;Tereshko, A. B.;Dikusar, E. A.. And the article was included in Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii) in 2004.Name: 4-Formyl-2-methoxyphenyl isobutyrate This article mentions the following:

Condensation of vanillin esters of aliphatic acids with 6-aminoquinoline and 1,3-cyclohexanedione or dimedone afforded new 2-methoxy-4-(11-oxo-7,8,9,10,11,12-hexahydrobenzo[b][4,7]-phenanthrolin-12-yl)phenyl esters of carboxylic acids. In the experiment, the researchers used many compounds, for example, 4-Formyl-2-methoxyphenyl isobutyrate (cas: 20665-85-4Name: 4-Formyl-2-methoxyphenyl isobutyrate).

4-Formyl-2-methoxyphenyl isobutyrate (cas: 20665-85-4) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Name: 4-Formyl-2-methoxyphenyl isobutyrate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis of 2-thiopheneacetic acid was written by Zhang, Junlin;Cheng, Hui;Qian, Yuejun. And the article was included in Zhongguo Yiyao Gongye Zazhi in 1993.Name: Methyl 2-thienylacetate This article mentions the following:

Treatment of 2-acetylthiophene with BF₃.OEt₂ and Pb(OAc)₄ in MeOH gave 74% Me 2-thiopheneacetate, hydrolysis of which with aqueous NaOH gave 95.7% the title compound In the experiment, the researchers used many compounds, for example, Methyl 2-thienylacetate (cas: 19432-68-9Name: Methyl 2-thienylacetate).

Methyl 2-thienylacetate (cas: 19432-68-9) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Name: Methyl 2-thienylacetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics