Month: February 2023

Synthesis of Zinc Tetraphenylporphyrin Rigid Rods with a Built-In Dipole was written by Chitre, Keyur;Batarseh, Alberto;Kopecky, Andrew;Fan, Hao;Tang, Hao;Lalancette, Roger;Bartynski, Robert A.;Galoppini, Elena. And the article was included in Journal of Physical Chemistry B in 2015.SDS of cas: 313648-56-5 This article mentions the following:

Three Zn(II) tetraphenylporphyrins (ZnTPP) were synthesized to study the influence of a mol. dipole on the energy level alignment of a chromophore bound to a metal oxide semiconductor: ZnTPP-PE(DA)-IpaOMe (1), ZnTPP-PE-IpaOMe (2), and ZnTPP-PE(AD)-IpaOMe (3). Each contained a rigid-rod linker made of a p-phenylene ethynylene (PE) moiety terminated with the Me ester of an isophthalic acid unit (Ipa). Porphyrins 1 and 3 contained an intramol. dipole in the central Ph ring, which was built by introducing electron donor (D, NMe₂) and acceptor (A, NO₂) substituents in para position to each other. In 1 and 3, the relative position of the D and A substituents, and therefore the dipole direction, was reversed. Porphyrin 2, without substituents in the linker, was synthesized for a comparison. The structures of precursors to 1 and 3 and the structure of 1 were determined by single crystal x-ray anal. Solution UV-visible and steady-state fluorescence spectra of 1–3 were identical to each other and exhibited the spectral features typical of the ZnTPP chromophore and their electrochem. properties were also very similar. Me esters 1–3 were hydrolyzed to the corresponding carboxylic acids for binding to metal oxide semiconductors. In the experiment, the researchers used many compounds, for example, Dimethyl 5-ethynylisophthalate (cas: 313648-56-5SDS of cas: 313648-56-5).

Dimethyl 5-ethynylisophthalate (cas: 313648-56-5) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.SDS of cas: 313648-56-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hydroxyindole Carboxylic Acid-Based Inhibitors for Receptor-Type Protein Tyrosine Protein Phosphatase Beta was written by Zeng, Li-Fan;Zhang, Ruo-Yu;Bai, Yunpeng;Wu, Li;Gunawan, Andrea M.;Zhang, Zhong-Yin. And the article was included in Antioxidants & Redox Signaling in 2014.Category: esters-buliding-blocks This article mentions the following:

Aims: Protein tyrosine phosphatases (PTPs) play an important role in regulating a wide range of cellular processes. Understanding the role of PTPs within these processes has been hampered by a lack of potent and selective PTP inhibitors. Generating potent and selective probes for PTPs remains a significant challenge because of the highly conserved and pos. charged PTP active site that also harbors a redox-sensitive Cys residue. Results: We describe a facile method that uses an appropriate hydroxyindole carboxylic acid to anchor the inhibitor to the PTP active site and relies on the secondary binding elements introduced through an amide-focused library to enhance binding affinity for the target PTP and to impart selectivity against off-target phosphatases. Here, we disclose a novel series of hydroxyindole carboxylic acid-based inhibitors for receptor-type tyrosine protein phosphatase beta (RPTP灏?, a potential target that is implicated in blood vessel development. The representative RPTP灏?inhibitor 8b-1 (L87B44) has an IC₅₀ of 0.38 娓璏 and at least 14-fold selectivity for RPTP灏?over a large panel of PTPs. Moreover, 8b-1 also exhibits excellent cellular activity and augments growth factor signaling in HEK293, MDA-MB-468, and human umbilical vein endothelial cells. Innovation: The bicyclic salicylic acid pharmacophore-based focused library approach may provide a potential solution to overcome the bioavailability issue that has plagued the PTP drug discovery field for many years. Conclusion: A novel method is described for the development of bioavailable PTP inhibitors that utilizes bicyclic salicylic acid to anchor the inhibitors to the active site and peripheral site interactions to enhance binding affinity and selectivity. Antioxid. Redox Signal. 20, 2130-2140. In the experiment, the researchers used many compounds, for example, tert-Butyl (3-ethynylphenyl)carbamate (cas: 185619-66-3Category: esters-buliding-blocks).

tert-Butyl (3-ethynylphenyl)carbamate (cas: 185619-66-3) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nanoporous well-defined reversible addition-fragmentation chain transfer polymer of N-acrylamido-L-tryptophan: synthesis and characterization was written by Singh, Pooja;Srivastava, Ambika;Kumar, Rajesh. And the article was included in Polymer International in 2014.Electric Literature of C14H12S2 This article mentions the following:

A nanoporous polymer with a chiral pendant chain of N-acrylamido-L-tryptophan was synthesized through a reversible addition-fragmentation chain transfer polymerization process using a dithiobenzoate derivative as chain transfer agent. The polymerization exhibited the usual characteristics of living processes, though slow polymerization rate and low percentage conversion for a chain extension experiment were observed Depending on the monomer/chain transfer agent ratio, poly(N-acrylamido-L-tryptophan) with number-average mol. weights between 640 and 4340 g mol^-1 and molar mass dispersities between 1.10 and 1.24 was obtained, as evidenced from gel permeation chromatog. SEM images indicated that the polymer was porous. Nitrogen adsorption anal. of the polymer evidenced the presence of mesopores (2-19 nm) associated with micropores (0.45-2 nm) according to the Barrett-Joyner-Halenda method with a specific Brunauer-Emmett-Teller surface area of 22.98 m2 g-1. 婕?2013 Society of Chem. Industry. In the experiment, the researchers used many compounds, for example, Benzyl benzodithioate (cas: 27249-90-7Electric Literature of C14H12S2).

Benzyl benzodithioate (cas: 27249-90-7) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Electric Literature of C14H12S2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Design, synthesis, insecticidal activity and 3D-QSR study for novel trifluoromethyl pyridine derivatives containing an 1,3,4-oxadiazole moiety was written by Xu, F. Z.;Wang, Y. Y.;Luo, D. X.;Yu, G.;Guo, S. X.;Fu, H.;Zhao, Y. H.;Wu, J.. And the article was included in RSC Advances in 2018.Name: Ethyl 2-(4-fluorophenyl)acetate This article mentions the following:

A series of trifluoromethyl pyridine derivatives containing 1,3,4-oxadiazole moiety I (R = H, 3-Cl-4-CH₃, 3-CH₃, etc.) was designed, synthesized and bio-assayed for their insecticidal activity. The result of bio-assays indicated the synthesized compounds exhibited good insecticidal activity against Mythimna separata and Plutella xylostella, most of the title compounds show 100% insecticidal activity at 500 mg L^-1 and >80% activity at 250 mg L^-1 against the two pests. Compounds I (R = 2-CF₃) and 2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-5-(4-fluorobenzyl)-1,3,4-oxadiazole showed LC₅₀ values of 38.5 and 30.8 mg L^-1 against Mythimna separata, resp., which were close to that of avermectin (29.6 mg L^-1). Compounds I (R = 3,5-Cl₂, 4-C₂H₅, 2-Cl-5-Br, 4-I, 3,4-Cl₂, 2-I, 3-N(CH₃)₂) and 2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-5-(4-fluorobenzyl)-1,3,4-oxadiazole showed 100% activity at 250 mg L^-1, which were better than chlorpyrifos (87%). CoMFA and CoMSIA models with good predictability were proposed, which revealed the electron-withdrawing groups with an appropriate bulk at 2- and 4-positions of benzene ring could enhance insecticidal activity. In the experiment, the researchers used many compounds, for example, Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2Name: Ethyl 2-(4-fluorophenyl)acetate).

Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters contain a carbonyl center, which gives rise to 120鎺?C閳ユ弲閳ユ彊 and O閳ユ弲閳ユ彊 angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C閳ユ彊閳ユ弲 bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Name: Ethyl 2-(4-fluorophenyl)acetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Preparation of alkyl aryl sulfides from alcohols and 2-sulfanylbenzothiazole by a new type of oxidation-reduction condensation using aryl diphenylphosphinite and benzoquinone derivatives was written by Kuroda, Kiichi;Hayashi, Yujiro;Mukaiyama, Teruaki. And the article was included in Chemistry Letters in 2008.COA of Formula: C11H14O3 This article mentions the following:

A method for the preparation of alkyl aryl sulfides from alcs. and 2-sulfanylbenzothiazole by a new type of oxidation-reduction condensation using Ph diphenylphosphinite and 2,6-dimethoxy-1,4-benzoquinone is described. In this reaction, the chiral alcs. are converted into the corresponding chiral sulfides with almost complete inversion of configurations under mild and neutral conditions. In the experiment, the researchers used many compounds, for example, Benzyl 2-hydroxy-2-methylpropanoate (cas: 19444-23-6COA of Formula: C11H14O3).

Benzyl 2-hydroxy-2-methylpropanoate (cas: 19444-23-6) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.COA of Formula: C11H14O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Unnatural 浼?amino ethyl esters from diethyl malonate or ethyl 灏?bromo-浼?hydroxyiminocarboxylate was written by Coutant, Eloi P.;Hervin, Vincent;Gagnot, Glwadys;Ford, Candice;Baatallah, Racha;Janin, Yves L.. And the article was included in Beilstein Journal of Organic Chemistry in 2018.Recommanded Product: 17920-23-9 This article mentions the following:

Explored the scope of the age-old di-Et malonate-based accesses to 浼?amino esters involving Knoevenagel condensations of di-Et malonate on aldehydes, reductions of the resulting alkylidenemalonates, the preparation of the corresponding 浼?hydroxyimino esters and their final reduction This synthetic pathway turned out to be general although some unexpected limitations were encountered. The synthetic modifications of some of the intermediates-using Suzuki-Miyaura coupling or cycloadditions -before undertaking the oximation step-provided accesses to further 浼?amino esters. Moreover, other pathways to 浼?hydroxyimino esters were explored including an attempt to improve the cycloadditions between Et 灏?bromo-浼?hydroxyiminocarboxylate and various alkylfuranes. In the experiment, the researchers used many compounds, for example, Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9Recommanded Product: 17920-23-9).

Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Recommanded Product: 17920-23-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Controlled synthesis of sulfonated block copolymers having thermoresponsive property by RAFT polymerization of vinyl sulfonate esters was written by Mori, Hideharu;Saito, Yosuke;Takahashi, Eri;Nakabayashi, Kazuhiro;Onuma, Atsuhiko;Morishima, Makoto. And the article was included in Polymer in 2012.COA of Formula: C14H12S2 This article mentions the following:

Four vinyl sulfonate ester derivatives, Me ethenesulfonate (MES), Et ethenesulfonate (EES), 2,2,2-trifluoroethyl ethenesulfonate (TFES), and 2,2,2-trichloroethyl ethenesulfonate (TCLES), which are protected forms of vinyl sulfonic acids, were polymerized by reversible addition-fragmentation chain transfer (RAFT) polymerization Polymers having relatively narrow mol. weight distributions and pre-determined mol. weights were obtained by the polymerization of all monomers using a suitable xanthate-type chain transfer agent (CTA). The RAFT polymerizations of EES and TCLES were found to proceed in controlled fashions under suitable conditions, as confirmed by the formation of narrow polydispersity products, mol. weights controlled by the monomer/chain transfer agent ratio, and linear increases in mol. weight with conversion. Deprotection of the Et group of poly(EES) by LiBr in refluxing 2-butanone proceeded smoothly to give water-soluble poly(lithium vinyl sulfonate). Poly(potassium vinyl sulfonate) was also obtained by the deprotection of poly(TCLES) using potassium tert-butoxide. The syntheses of thermoresponsive block copolymers involving poly(lithium vinyl sulfonate) segments were conducted by RAFT polymerization of N-isopropylacrylamide using poly(EES) macro-CTA, followed by deprotection. ^THe thermally-induced phase separation behavior and assembled structures of the block copolymers were also studied in aqueous solution In the experiment, the researchers used many compounds, for example, Benzyl benzodithioate (cas: 27249-90-7COA of Formula: C14H12S2).

Benzyl benzodithioate (cas: 27249-90-7) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is 绾?valerolactone.COA of Formula: C14H12S2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dehydrogenative alcohol coupling and one-pot cross metathesis/dehydrogenative coupling reactions of alcohols using Hoveyda-Grubbs catalysts was written by Ozer, Halenur;Arslan, Dilan;Ozturk, Bengi Ozgun. And the article was included in New Journal of Chemistry in 2021.Safety of Isopentyl 3-methylbutanoate This article mentions the following:

In this study, in situ formed ruthenium hydride species that were generated from Grubbs type catalysts are used as efficient catalysts for dehydrogenative alc. coupling and sequential cross-metathesis/dehydrogenative coupling reactions. The selectivity of Grubbs first generation catalysts (G1, I) in dehydrogenative alc. coupling reactions can be tuned for the ester (octyl octanoate) formation in the presence of weak bases, while the selectivity can be switched to the 灏?alkylated alc. (2-hexyyl-1-decanol) formation using strong bases. The performance of Hoveyda-Grubbs 2nd generation catalyst (HG2) was improved in the presence of tricyclohexylphosphine for the selective synthesis of ester derivatives RC(O)OR¹ (R = heptyl, Ph, dec-9-en-1-yl, etc.; R¹ = H, octyl, Bn, etc.) and with 绾?butyrolactone weak and strong bases in quant. yields. Allyl alc. was used as self and cross-metathesis substrate for the HG2 catalyzed sequential cross-metathesis/dehydrogenative alc. coupling reactions to obtain 绾?butyrolactone and long-chain ester derivatives in quant. yields. In the experiment, the researchers used many compounds, for example, Isopentyl 3-methylbutanoate (cas: 659-70-1Safety of Isopentyl 3-methylbutanoate).

Isopentyl 3-methylbutanoate (cas: 659-70-1) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Safety of Isopentyl 3-methylbutanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Distinct Spacing Between Anionic Groups: An Essential Chemical Determinant for Achieving Thiophene-Based Ligands to Distinguish 灏?Amyloid or Tau Polymorphic Aggregates was written by Klingstedt, Therese;Shirani, Hamid;Mahler, Jasmin;Wegenast-Braun, Bettina M.;Nystroem, Sofie;Goedert, Michel;Jucker, Mathias;Nilsson, K. Peter R.. And the article was included in Chemistry – A European Journal in 2015.HPLC of Formula: 19432-68-9 This article mentions the following:

The accumulation of protein aggregates is associated with many devastating neurodegenerative diseases and the existence of distinct aggregated morphotypes has been suggested to explain the heterogeneous phenotype reported for these diseases. Thus, the development of mol. probes able to distinguish such morphotypes is essential. We report an anionic tetrameric oligothiophene compound that can be utilized for spectral assignment of different morphotypes of 灏?amyloid or tau aggregates present in transgenic mice at distinct ages. The ability of the ligand to spectrally distinguish between the aggregated morphotypes was reduced when the spacing between the anionic substituents along the conjugated thiophene backbone was altered, which verified that specific mol. interactions between the ligand and the protein aggregate are necessary to detect aggregate polymorphism. Our findings provide the structural and functional basis for the development of new fluorescent ligands that can distinguish between different morphotypes of protein aggregates. In the experiment, the researchers used many compounds, for example, Methyl 2-thienylacetate (cas: 19432-68-9HPLC of Formula: 19432-68-9).

Methyl 2-thienylacetate (cas: 19432-68-9) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters contain a carbonyl center, which gives rise to 120鎺?C閳ユ弲閳ユ彊 and O閳ユ弲閳ユ彊 angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C閳ユ彊閳ユ弲 bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. HPLC of Formula: 19432-68-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Aromatic profile of Sagrantino grape and wine was written by Di Stefano, R.;Mattivi, F.;Caburazzi, M.;Bonifazi, L.. And the article was included in Rivista di Viticoltura e di Enologia in 2009.Computed Properties of C11H14O3 This article mentions the following:

Sagrantino grapes and wines were analyzed for extracted glycoconjugated volatile compounds The compounds were extracted with methanol, the free and glycosidic forms were separated on Isolute C₁₈ cartridges, and the glycosidic forms were hydrolyzed enzymically (Pectinase CLX-150). The volatiles were determined by GC-MS with 1-heptanol as internal standard The influence of the vinification process (fermentation, maturation, aging) was evaluated by anal. of the free and glycoconjugated compounds The Sagrantino grapes had significant contents of glycoconjugated terpene compounds, such as trans-geranic acid, 浼?terpineol, furan linalool oxides, linalool, geraniol, nerol, and 2 isomers of 8-hydroxylinalool. The wines showed decreases of linalool levels, while 浼?terpineol, furan linalool oxides, trans-geranic acid, the 2 isomers of 8-hydroxylinalool, geraniol, and nerol were quant. important. Some compounds, including norisoprenoids, were of marginal importance in grapes but became relevant in wines. Hypotheses have been formulated to explain these results. In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxy-3-phenylpropanoate (cas: 15399-05-0Computed Properties of C11H14O3).

Ethyl 2-hydroxy-3-phenylpropanoate (cas: 15399-05-0) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Computed Properties of C11H14O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics