Month: February 2023

Synthesis of 浼? 灏?unsaturated 绾?amino esters with unprecedented high (E)-stereoselectivity and their conformational analysis in peptides was written by Mali, Sachitanand M.;Bandyopadhyay, Anupam;Jadhav, Sandip V.;Kumar, Mothukuri Ganesh;Gopi, Hosahudya N.. And the article was included in Organic & Biomolecular Chemistry in 2011.HPLC of Formula: 87694-53-9 This article mentions the following:

Mild, efficient and racemization-free synthesis of N-protected 浼? 灏?unsaturated 绾?amino esters with unprecedented high E- stereoselectivity is described. This method is found to be compatible with Boc- (Boc = tert-butoxycarbonyl), Fmoc- (Fmoc = 9-fluorenylmethoxycarbonyl) and other side chain protecting groups. The crystal conformations of the vinylogous 绾?amino esters in monomers and in homo- and mixed dipeptides are studied. Further, the vinylogous homo-dipeptide showed a 灏?sheet conformation, while mixed 浼? and 浼?灏?unsaturated 绾?hybrid dipeptide adapted an irregular structure in single crystals. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9HPLC of Formula: 87694-53-9).

(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.HPLC of Formula: 87694-53-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Properties and structure of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) filaments for fused deposition modelling was written by Kovalcik, Adriana;Smilek, Jiri;Machovsky, Michal;Kalina, Michal;Enev, Vojtech;Dugova, Hana;Cernekova, Nicole;Kovacova, Maria;Spitalsky, Zdenko. And the article was included in International Journal of Biological Macromolecules in 2021.Category: esters-buliding-blocks This article mentions the following:

Fused deposition modeling (FDM) is a process of additive manufacturing allowing creating of highly precise complex three-dimensional objects for a large range of applications. The principle of FDM is an extrusion of the molten filament and gradual deposition of layers and their solidification. Potential applications in pharmaceutical and medical fields require the development of biodegradable and biocompatible thermoplastics for the processing of filaments. In this work, the potential of production of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P(3HB-co-4HB)) filaments for FDM was investigated in respect to its thermal stability. Copolymer P(3HB-co-4HB) was biosynthesised by Cupriavidus malaysiensis. Rheol. and mech. properties of the copolymer were modified by the addition of plasticizers or blending with poly(lactic acid). Thermal stability of mixtures was studied employing thermogravimetric anal. and rheol. analyses by monitoring the time-dependent changes in the complex viscosity of melt samples. The plasticization of P(3HB-co-4HB) slightly hindered its thermal degradation but the best stabilization effect was found in case of the copolymer blended with poly(lactic acid). Overall, rheol., thermal and mech. properties demonstrated that the plasticized P(3HB-co-4HB) is a potential candidate of biodegradable polymer for FDM processes. In the experiment, the researchers used many compounds, for example, 2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8Category: esters-buliding-blocks).

2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is 绾?valerolactone.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rhenium-Catalyzed Construction of Polycyclic Hydrocarbon Frameworks by a Unique Cyclization of 1,n-Diynes Initiated by 1,1-Difunctionalization with Carbon Nucleophiles was written by Murai, Masahito;Uemura, Erika;Hori, Shunsuke;Takai, Kazuhiko. And the article was included in Angewandte Chemie, International Edition in 2017.COA of Formula: C10H14O4 This article mentions the following:

A regioselective cyclization of 1,n-diynes under rhenium catalysis was developed on the basis of a rare type of 1,1-difunctionalization of terminal alkynes with carbon nucleophiles, followed by sequential addition reactions of the resulting alkenylrhenium species. The reaction provides an efficient approach to the synthesis of complex cyclopentane-fused bi- and tricycles and spirocycles, which are useful building blocks for the construction of essential frameworks of biol. active compounds as well as functional materials, from simple starting materials by the formation of up to six new carbon-carbon bonds in a single step. The reaction proceeds under neutral conditions and does not require external ligands or additives. The key to this reactivity is the unique activation mode of the rhenium carbonyl complex, which prefers to interact with heteroatoms in polar carbon-heteroatom bonds as well as nonpolar carbon-carbon unsaturated 锜?bonds. In the experiment, the researchers used many compounds, for example, Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9COA of Formula: C10H14O4).

Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.COA of Formula: C10H14O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Experiments on the Walden Inversion. VII. Action of Phosphorus Pentachloride and of Thionyl Chloride on Optically Active Hydroxy Acids and Esters was written by McKenzie, Alex;Barrow, Fred. And the article was included in Journal of the Chemical Society, Transactions in 1911.Recommanded Product: 15399-05-0 This article mentions the following:

Phenylchloroacetic acid and benzylidene chloride are formed from SOCl₂ and dl-mandelic acid. l-Mandelic acid gives l-phenylchloroacetic acid, which, with Ag₂CO₃ and H₂O, forms d-mandelic acid. Me l-mandelate gives methyl l-phenylchloroacetate, PhCHClCO₂Me; b₁₁ 123-6鎺? d₄¹⁵ 1.213; [浼猐_D¹⁵ -86.7鎺? It gave l-phenylchloroacetic acid. From the ester and MeONa was obtained dl-phenylmethoxyacetic acid. Et l-mandelate gave ethyl l-phenylchloroacetate; b₁₃ 132-3鎺? d₄^16.4 1.162; [浼猐_D^16.4 -64.00. It gave l-phenylchloroacetic acid. The ester and EtONa gave dl-phenylethoxyacetic acid. l-Malie acid and SOCl₂ form d-chlorosuccinic acid. Et l-malate produced ethyl d-chlorosuccinate, EtO₂CCH₂CHClCO₂Et; b₁₆ 124鎺? d₄^19.5 1.152; [浼猐_D^19.8 32.7鎺? Et d-tartrate and SOCl₂ give from which d-tartaric acid was produced. Ethyl d,浼?hydroxy-灏?phenzylpropionate. PhCH₂OH(OH)CO₂Et, b₂ 152-4鎺? d₄¹⁷ 1.105; [浼猐_D¹⁷ 7.6鎺?m. 46-7鎺? in alc.[浼猐_D^18.6 -4.8鎺? in C₆H₆, [浼猐_D^17.5 22.5鎺? in acetone, [浼猐_D^17.5 13.6鎺? Ethyl l,浼?hydroxy-灏?phenvlpropionate b₂₀ 159-60鎺? m. 46-7鎺? in C₆H₆ [浼猐_D¹³ -22.6鎺? With PCl₃ the product is l-rotatory and the resulting Ca salt d-rotatory, in H₂O. The d-ester gave a similar result. The l-acid and PCl, gave a product l-rotatory in alc. Et l,浼?hydroxy-灏?phenylpropionate and SOCl₂ gave a d-rotatory product which formed a Ca salt that was l-rotatory in H₂O. d,灏?Hydroxy-灏?phenylpropionic acid and concentrate HCl gave a chloro acid having [浼猐_D -4.6鎺? in alc. With H₂O a hydroxy acid had 浼?sub>D 0.29鎺? in alc. With the l,灏?hydroxy-灏?phenylpropionic acid and HCl the products had [浼猐_D 6.5-21.8鎺? d,灏?Hydroxy-灏?phenylproplonic acid and PCl₃ gave a l-rotatory chloro acid, which, with moist Et₂O gave a l-rotatory compound With SOCl₂, instead of PCl₃, the products are cinnamic and dl- and d,灏?chloro-灏?phenylpropionic acids. B. H₂O converts these latter into dl- and l,灏?hydroxy-灏?phenylpropionic acids. l,灏?Hydroxy-灏?phenylpropionic acid and SOCl₂ formed cinnamic and dl- and l,灏?chloro-灏?phenylpropionic acids, from which, with H₂O, some d-hydroxy acid was produced. In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxy-3-phenylpropanoate (cas: 15399-05-0Recommanded Product: 15399-05-0).

Ethyl 2-hydroxy-3-phenylpropanoate (cas: 15399-05-0) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Recommanded Product: 15399-05-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cross-Linked Enzyme-Adhered Nanoparticles (CLEANs) for Continuous-Flow Bioproduction was written by Nagy, Flora;Santa-Bell, Evelin;Jipa, Monica;Hornyanszky, Gabor;Szilagyi, Andras;Laszlo, Krisztina;Katona, Gabriel;Paizs, Csaba;Poppe, Laszlo;Balogh-Weiser, Diana. And the article was included in ChemSusChem in 2022.Synthetic Route of C12H20O2 This article mentions the following:

Nanostructured but micro-sized biocatalysts were created by bottom-up technol. using multi-functionalized silica nanoparticles (NPs) as nano-sized building blocks to form cross-linked enzyme-adhered nanoparticles (CLEANs) as robust micro-sized particles with beneficial internal structure and good mech. properties. Systematic surface modification of NPs with a grafting mixture consisting of organosilanes with reactive (aminopropyl) and inert (e. g., vinyl, Pr, Ph, or octyl) functions resulted in functional NPs enabling crosslinking agents, such as glutardialdehyde or bisepoxides (glycerol diglycidyl ether, neopentylglycol diglycidyl ether, and poly(propylene glycol) diglycidyl ether), to bind and cross-link enzymes covalently and to form macroporous microparticles. These CLEANs were able to diminish several weaknesses of traditional cross-linked enzyme aggregates as biocatalysts, such as poor mech. resistance, difficult recovery, and storage, strengthening their use for packed-bed enzyme reactors. Lipase B from Candida antarctica (CaLB) was selected as model enzyme for development of robust CLEANs, which were successfully tested for various industrially relevant applications including a kinetic resolution of a racemic alc. and the production of various natural fragrance compounds under continuous-flow conditions. In the experiment, the researchers used many compounds, for example, (E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3Synthetic Route of C12H20O2).

(E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Synthetic Route of C12H20O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

灏?Keto esters from ketones and ethyl chloroformate: a rapid, general, efficient synthesis of pyrazolones and their antimicrobial, in鑱?em>silico and in鑱?em>vitro cytotoxicity studies was written by Ragavan, Ramasamy Venkat;Kumar, Kalavathi Murugan;Vijayakumar, Vijayaparthasarathi;Sarveswari, Sundaramoorthy;Ramaiah, Sudha;Anbarasu, Anand;Karthikeyan, Sivashanmugam;Giridharan, Periyasamy;Kumari, Nalilu Suchetha. And the article was included in Organic and Medicinal Chemistry Letters in 2013.Safety of Ethyl 3-oxo-3-(thiophen-2-yl)propanoate This article mentions the following:

A series of pyrazolones I [R¹ = Ph, 4-MeOC₆H₄, cyclohexyl, 3-Cl(CH₂)₃, etc.; R² = H, Me, Et; R³ = H, 4-FC₆H₄; R¹R² = (CH₂)₆, (CH₂)₈, etc.] were synthesized via cross-Claisen condensation of ketones and Et chloroformate to give 灏?keto esters which further reacted with hydrazine derivatives, and their cytotoxicity and antimicrobial activity were studied. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Safety of Ethyl 3-oxo-3-(thiophen-2-yl)propanoate).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Safety of Ethyl 3-oxo-3-(thiophen-2-yl)propanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Discovery of a 1-Methyl-3,4-dihydronaphthalene-Based Sphingosine-1-Phosphate (S1P) Receptor Agonist Ceralifimod (ONO-4641). A S1P₁ and S1P₅ Selective Agonist for the Treatment of Autoimmune Diseases was written by Kurata, Haruto;Kusumi, Kensuke;Otsuki, Kazuhiro;Suzuki, Ryo;Kurono, Masakuni;Komiya, Takaki;Hagiya, Hiroshi;Mizuno, Hirotaka;Shioya, Hiroki;Ono, Takeji;Takada, Yuka;Maeda, Tatsuo;Matsunaga, Norikazu;Kondo, Tetsu;Tominaga, Sachiko;Nunoya, Ken-ici;Kiyoshi, Hidekazu;Komeno, Masaharu;Nakade, Shinji;Habashita, Hiromu. And the article was included in Journal of Medicinal Chemistry in 2017.Name: Methyl 4-Hydroxy-2-methoxybenzoate This article mentions the following:

The discovery of 1-({6-[(2-methoxy-4-propylbenzyl)oxy]-1-methyl-3,4-dihydronaphthalen-2-yl}methyl)azetidine3-carboxylic acid (I) (13n, ceralifimod, ONO-4641), a sphingosine-1-phosphate (S1P) receptor agonist selective for S1P₁ and S1P₅, is described. While it has been revealed that the modulation of the S1P₁ receptor is an effective way to treat autoimmune diseases such as relapsing-remitting multiple sclerosis (RRMS), it was also reported that activation of the S1P₃ receptor is implicated in some undesirable effects. The authors carried out a structure-activity relationship (SAR) study of hit compound 6 with an amino acid moiety in the hydrophilic head region. Following identification of a lead compound with a dihydronaphthalene central core by inducing conformational constraint, optimization of the lipophilic tail region led to the discovery of I as a clin. candidate that exhibited >30 000-fold selectivity for S1P₁ over S1P₃ and was potent in a peripheral lymphocyte lowering (PLL) test in mice (ED₅₀ = 0.029 mg/kg, 24 h after oral dosing). In the experiment, the researchers used many compounds, for example, Methyl 4-Hydroxy-2-methoxybenzoate (cas: 28478-46-8Name: Methyl 4-Hydroxy-2-methoxybenzoate).

Methyl 4-Hydroxy-2-methoxybenzoate (cas: 28478-46-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Name: Methyl 4-Hydroxy-2-methoxybenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Amino sugar synthesis. XVII. Synthesis of D-rhamnosamine and of 2,6-diamino-2,6-dideoxy-D-mannose from N-acetyl-D-mannosamine was written by Gross, Paul H.;Brendel, Klaus;Zimmerman, Howard K. Jr.. And the article was included in Justus Liebigs Annalen der Chemie in 1966.Synthetic Route of C16H23NO10 This article mentions the following:

2-acetamido-2-deoxy-D-mannose-H₂O (I) by 2 distillations under reduced pressure with 500 ml. 1:2 C₆H₆-EtOH azeotrope, then addition of 40 g. Dowex 50WX2 (H⁺ form) resin (similarly dehydrated), distillation with 2.5 l. azeotrope slowly at 760 mm., and working up the EtOH solution and washings gave 15.5 g. sirupy Et 2-acetamido-2-deoxy-D-mannoside (II), giving a neg. Fehling test and consuming 0.9 mole NaIO₄ in 6 hrs. (0.15-0.2 mole HCHO formed). Extracting the resin with 150 ml. 2N HCl 6 times gave 6 g. 2-amino-2-deoxy-D-mannose-HCl (III), [浼猐²³_D -4鎺?(c 0.33, H₂O). 2-Acetamidotetra-O-acetyl-2-deoxy-灏?D-mannose, obtained from I or III with Ac₂O and C₅H₅N, m. 160-1鎺? [浼猐²⁵_D – 19鎺? II (3 g.) and Ph₃CCl in C₅H₅N 2 hrs. at 90鎺?gave 4.6 g. 6-O-trityl ether, m. 160-1鎺? [浼猐²³_D -9鎺?(c 2, C₅H₅N); hydrolysis of the Ph₃C group with aqueous HOAc and NaIO₄ oxidation showed 19% furanoside. II triacetate (from Ac₂O and C₅H₅N 10 hrs. at room temperature) was a sirup, [浼猐²³_D 60鎺?(c 3.6, CHCl₃). Reaction of 10 g. II and 8 g. p-MeC₆H₄SO₂Cl in C₅H₅N 8 days at 0鎺?then addition of 12 ml. Ac₂O and reaction 36 hrs. at 0鎺?gave 34% 6-(O-p-tolylsulfonyl) derivative (IV), m. 135-6鎺? [浼猐²³_D 54鎺?(c 2, C₅H₅N). Heating IV with KOAc, Ac₂O, and AcOH 15 hrs. at 130鎺?gave, not the expected II triacetate, but a half-crystalline substance, which was deacetylated and showed, by NaIO₄ oxidation, a 5% furanoside content. Heating IV and NaI in EtAc 15 hrs. at 110鎺?gave 88% 6-deoxy-6-iodo derivative, m. 56-8鎺? [浼猐²³_D 44鎺?(c 2, C₅H₅N), hydrogenated over Raney Ni 10 hrs., and the product hydrolyzed in 2N HCl 1 hr. at 60鎺? then 2 hrs. at 100鎺? to give 71% 2-amino-2,6-dideoxy-D-mannose-HCl, m. 175鎺?(decomposition), [浼猐²⁵_D -28鎺?(5 min.) to -23鎺?(4 hrs.) (c 0.33, H₂O), [浼猐²⁵₅₄₆ -26鎺?(12 hrs., c 0.33, H₂O). The 6-azido-6-deoxy derivative, prepared from 4.87 g. IV and 5 g. NaN₃ in 25 ml. Me₂SO 3 hrs. at 110鎺? 98% yield, was an oil, which was hydrogenated 5 hrs. over Pd black in MeOH and Ac₂O to give 74% Et 2,6-diacetamido-3,4-di-O-acetyl-2,6-dideoxy-浼?D-mannopyranoside, m. 225-6鎺? [浼猐)²⁴_D 71鎺?(c 2, C₅H₅N), and then hydrolyzed 1 hr. at 60鎺?and 2 hrs. at 100鎺?in 3N HCl to give 72% 2,6-diamino-2,6-dideoxy-浼?D-mannose-2 HCl, m. 135-6鎺?[浼猐²⁴_D 9鎺?(10 min.) to -1鎺?(25 hrs.). Reaction of 50 mg. 2,6-diamino-2,6-dideoxy-浼?D-glucose-2HCl in 1 ml. H₂O, and 5 ml. MeOH with 7 ml. 1% AgOAc and 0.5 ml. Ac₂O 48 hrs. in the dark, treatment with cation-exchange resin, and crystallization from MeCH(OMe)₂ gave 35 mg. 2,6-diacetamido-2,6-dideoxy-浼?D-glucose, m. 208-9鎺?(decomposition), [浼猐²⁰_D 36鎺?(2 hrs.) to 32鎺?(15 hrs., c 0.5, H₂O). In the experiment, the researchers used many compounds, for example, (2S,3S,4R,5S,6R)-3-Acetamido-6-(acetoxymethyl)tetrahydro-2H-pyran-2,4,5-triyl triacetate (cas: 6730-10-5Synthetic Route of C16H23NO10).

(2S,3S,4R,5S,6R)-3-Acetamido-6-(acetoxymethyl)tetrahydro-2H-pyran-2,4,5-triyl triacetate (cas: 6730-10-5) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Synthetic Route of C16H23NO10

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Three-Component Minisci Reaction with 1,3-Dicarbonyl Compounds Induced by Visible Light was written by Li, Tao;Liang, Kangjiang;Zhang, Yang;Hu, Dongyan;Ma, Zhixian;Xia, Chengfeng. And the article was included in Organic Letters in 2020.Electric Literature of C9H10O3S This article mentions the following:

A three-component Minisci reaction coupling of 1,3-dicarbonyl compounds with vinyl ethers and quinolines or isoquinolines under visible light is developed. The 1,3-dicarbonyl compound undergoes single-electron oxidation to afford an electrophilic 1,3-dicarbonyl radical under visible light irradiation Due to the polarity of the free radical, the electrophilic radical adds to the electron-rich olefin to afford the nucleophilic radical. It coupled with the heteroarene to afford the three-component coupling products. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Electric Literature of C9H10O3S).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Electric Literature of C9H10O3S

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Design, synthesis and biological evaluation of nuclear receptor-degradation inducers was written by Itoh, Yukihiro;Kitaguchi, Risa;Ishikawa, Minoru;Naito, Mikihiko;Hashimoto, Yuichi. And the article was included in Bioorganic & Medicinal Chemistry in 2011.Quality Control of Methyl 2-methoxy-4-methylbenzoate This article mentions the following:

Compounds that regulate the function(s) of nuclear receptors (NRs) are useful for biol. studies and as candidate therapeutic agents. Most such compounds are agonists or antagonists. We have developed specific protein degradation inducers, which we designated as SNIPERs (Specific and Nongenetic IAPs-dependent Protein ERasers), for selective degradation of target proteins. SNIPERs are hybrid mols. consisting of an appropriate ligand for the protein of interest, coupled to a ligand for inhibitor of apoptosis proteins (IAPs), which target the bound protein for polyubiquitination and proteasomal degradation We considered that protein knockdown with SNIPERs would be a promising alternative approach for modulating NR function. In this study, we designed and synthesized degradation inducers targeting retinoic acid receptor (RAR), estrogen receptor (ER), and androgen receptor (AR). These newly synthesized RAR, ER, and AR SNIPERs, 9, 11, and 13, resp., were confirmed to significantly reduce the levels of the corresponding NRs in live cells. In the experiment, the researchers used many compounds, for example, Methyl 2-methoxy-4-methylbenzoate (cas: 81245-24-1Quality Control of Methyl 2-methoxy-4-methylbenzoate).

Methyl 2-methoxy-4-methylbenzoate (cas: 81245-24-1) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Quality Control of Methyl 2-methoxy-4-methylbenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics