Month: February 2023

Enolizability of S-alkyl esters of thioacetoacetic and thiomalonic acids was written by Kurgane, B.;Grinvalde, A.;Stradins, J.;Brakmane, M.;Hillers, S.. And the article was included in Zhurnal Organicheskoi Khimii in 1974.Recommanded Product: malonic acid dibutyl ester This article mentions the following:

MeCOCH2CO2R (I), MeCOCH2COSR (II), RO2CCH2CO2R (III), and RSCOCH2COSR (IV), (R = Et, CH2CH2Cl, Me2CH, PhCH2, Ph), were prepared; 6-11% I and 19-28% II were in the enol form, but III and IV existed completely in the diketo form. In the experiment, the researchers used many compounds, for example, malonic acid dibutyl ester (cas: 1190-39-2Recommanded Product: malonic acid dibutyl ester).

malonic acid dibutyl ester (cas: 1190-39-2) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Recommanded Product: malonic acid dibutyl ester

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pd-Catalyzed Regioselective Alkoxycarbonylation of 1-Alkenes Using a Lewis Acid [SnCl₂ or Ti(OⁱPr)₄] and a Phosphine was written by Amezquita-Valencia, Manuel;Achonduh, George;Alper, Howard. And the article was included in Journal of Organic Chemistry in 2015.Safety of Dimethyl decanedioate This article mentions the following:

The phosphine ligand mediated palladium catalyzed alkoxycarbonylation of alkenes was investigated with the objective of attaining good linear selectivity for the ester. The effect of various parameters such as solvents, additives, palladium precursors, CO pressures, and alkenes of various structural complexities were examined The results revealed the importance of using a Lewis acid such as SnCl₂ or Ti(OⁱPr)₄ in combination with a monodentate ligand such CYTOP 292 or P(p-anisyl)₃ to enhance the regioselectivity for the linear isomers in the range of 70-96%. In the experiment, the researchers used many compounds, for example, Dimethyl decanedioate (cas: 106-79-6Safety of Dimethyl decanedioate).

Dimethyl decanedioate (cas: 106-79-6) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Safety of Dimethyl decanedioate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fabrication of Pb²⁺ ion selective electrode based on 1-((3-((2-hydroxynaphthalen-1-yl)methyleneamino)-2,2-dimethylpropylimino) methyl) naphthalen-2-ol as new neutral ionophore was written by Ghaedi, M.;Montazerozohori, M.;Andikaey, Z.;Shokrollahi, A.;Khodadoust, S.;Behfar, M.;Sharifi, S.. And the article was included in International Journal of Electrochemical Science in 2011.Electric Literature of C12H22O4 This article mentions the following:

The potentiometric study of complexation of 1-((3-((2-hydroxynaphthalen-1-yl)methyleneamino)-2,2-dimethylpropylimino)Me) naphthalen-2-ol (HMDMN) show strong interaction between HMDMN and Pb²⁺ ion while their formation constant was evaluated using potentiometric data. The suitability of the HMDMN for construction of new Pb²⁺ ion PVC membrane electrode and its potentiometric determination was studied. The influence of variables including pH, membrane ingredients was optimized and set as PVC:DBP:carrier:NaTPB:NaTPB/carrier mole ratio with the percent mass ratio of 28.9:57.8:8.0:5.33:0.83. At optimum values of all variables the electrode response is linear in the concentration range of 1.0 鑴?10^-6 to 0.1M with detection limit 4.0 鑴?10^-7 M with Nernstian slop of 25.79 mV/decade over the pH range of 5.0-7.2. This electrode with appropriate response time 閳?0s and suitable reproducibility (relative standard deviation), can be used for at least 2 mo without any measurable divergence in response properties. The proposed sensor reveals good selectivity toward Pb²⁺ ion with respect to many alkali, alk. earth, transition and heavy metal ions. It was applied to the determination of Pb²⁺ in water and soil samples. In the experiment, the researchers used many compounds, for example, Dimethyl decanedioate (cas: 106-79-6Electric Literature of C12H22O4).

Dimethyl decanedioate (cas: 106-79-6) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Electric Literature of C12H22O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Studies directed toward the preparation of key intermediates for the synthesis of trisporic acids and cassiol was written by Colombo, Maria I.;Zinczuk, Juan;Mischne, Mirta P.;Ruveda, Edmundo A.. And the article was included in Pure and Applied Chemistry in 2001.COA of Formula: C9H16O4 This article mentions the following:

An enantioselective synthesis and resolution of the key White intermediate I for the synthesis of trisporic acids are described. Attempts to develop a synthetic route toward the antiulcerogenic compound cassiol (II) by an olefination reaction of I and an alternative sequence involving a Michael addition followed by an aldol condensation of an open substrate, are also reported. In the experiment, the researchers used many compounds, for example, Ethyl 2,2-dimethyl-1,3-dioxane-5-carboxylate (cas: 82962-54-7COA of Formula: C9H16O4).

Ethyl 2,2-dimethyl-1,3-dioxane-5-carboxylate (cas: 82962-54-7) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.COA of Formula: C9H16O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Janus glycosides of next generation: Synthesis of 4-(3-chloropropoxy)phenyl and 4-(3-azidopropoxy)phenyl glycosides was written by Stepanova, Elena V.;Abronina, Polina I.;Zinin, Alexander I.;Chizhov, Alexander O.;Kononov, Leonid O.. And the article was included in Carbohydrate Research in 2019.Product Details of 4163-60-4 This article mentions the following:

Efficient procedures for the preparative synthesis of per-O-acyl derivatives of 4-(3-chloropropoxy)phenyl (CPP) glycosides of a series of common mono- and disaccharides (D-glucose, D-galactose, D-mannose, L-rhamnose, D-arabinofuranose, D-glucosamine, lactose) are described. The CPP glycosides obtained were transformed in almost quant. yields to the corresponding unprotected 4-(3-azidopropoxy)phenyl (APP) glycosides, which could become next-generation Janus glycosides with cleavable spacer aglycon, ready for conjugation or further transformation. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4Product Details of 4163-60-4).

(2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Product Details of 4163-60-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Phenyl bioisosteres in medicinal chemistry: discovery of novel 绾?secretase modulators as a potential treatment for Alzheimer閳ョ灚 disease was written by Ratni, H.;Baumann, K.;Bellotti, P.;Cook, X. A.;Green, L. G.;Luebbers, T.;Reutlinger, M.;Stepan, A. F.;Vifian, W.. And the article was included in RSC Medicinal Chemistry in 2021.Safety of Methyl 4-aminobicyclo[2.2.2]octane-1-carboxylate This article mentions the following:

Ph rings are one of the most prevalent structural moieties in active pharmaceutical ingredients, even if they often contribute to poor physico-chem. properties. Herein, we propose the use of a bridged piperidine (BP) moiety as a Ph bioisostere, which could also be seen as a superior Ph alternative as it led to strongly improved drug like properties, in terms of solubility and lipophilicity. Addnl., this BP moiety compares favorably to the recently reported saturated Ph bioisosteres. We applied this concept to our 绾?secretase modulator (GSM) project for the potential treatment of Alzheimer閳ョ灚 disease delivering clin. candidates. In the experiment, the researchers used many compounds, for example, Methyl 4-aminobicyclo[2.2.2]octane-1-carboxylate (cas: 135908-33-7Safety of Methyl 4-aminobicyclo[2.2.2]octane-1-carboxylate).

Methyl 4-aminobicyclo[2.2.2]octane-1-carboxylate (cas: 135908-33-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Safety of Methyl 4-aminobicyclo[2.2.2]octane-1-carboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

A facile approach to trans-4,5-pyrrolidine lactam and application in the synthesis of nemonapride and streptopyrrolidine was written by Huang, Wei;Ma, Jing-Yi;Yuan, Mu;Xu, Long-Fei;Wei, Bang-Guo. And the article was included in Tetrahedron in 2011.Recommanded Product: (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate This article mentions the following:

An efficient approach to trans-4-hydroxylpyrrolidine lactams, e.g. I [R¹ = t-Bu, PhCH₂; R² = H, Me; Me₂CH, etc.; R³ = H, TBSO], starting from an amino acid is described. The utility of this method has been demonstrated in the synthesis of antipsychotic nemonapride and antiangiogenic streptopyrrolidine. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9Recommanded Product: (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate).

(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Recommanded Product: (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Aminopyrazine Pathway to the Moco Metabolite Dephospho Form A was written by Klewe, Anne;Kruse, Tobias;Lindel, Thomas. And the article was included in Chemistry – A European Journal in 2017.Category: esters-buliding-blocks This article mentions the following:

An efficient synthesis of the molybdopterin/molybdenum cofactor (Moco) oxidation product dephospho Form A I is described that assembles the pteridinone system starting from an iodinated aminopyrazine. The sodium salt of dephospho Form A could be purified by precipitation from methanol, which paved the way to the title compound in the 100 mg range. By HPLC, the synthetic material was compared with a sample isolated from a recombinant Moco containing protein. Anal. of dephospho Form A is the only method that allows the quantification of the Moco content of crude cell extracts and recombinant protein preparations In the experiment, the researchers used many compounds, for example, Methyl 2-aminonicotinate (cas: 14667-47-1Category: esters-buliding-blocks).

Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters contain a carbonyl center, which gives rise to 120鎺?C閳ユ弲閳ユ彊 and O閳ユ弲閳ユ彊 angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C閳ユ彊閳ユ弲 bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chemical composition, phenolic content and antioxidant capacity of Haloxylon scoparium extracts was written by Haida, S.;Kribii, A.. And the article was included in South African Journal of Botany in 2020.Reference of 106-79-6 This article mentions the following:

This work is part of the valorization of the Haloxylon scoparium plant, belonging to the Chenopodiaceae family and native to southeastern of Morocco. The aim of the present work is to study the chem. composition of this plant, to estimate the phenolic compounds contents of its extracts and to evaluate their antioxidant powers. After extraction by maceration of the aerial and root part of Haloxylon scoparium, the extracts obtained are fractionated by liquid-liquid extraction using solvents of different polarities. The best extraction yield is obtained in the aerial part 23.54% against 10.99% for the root part. The anal. carried out by the coupling of gas chromatog. with mass spectrometry (GC-MS) shows that the root part contains mainly carbohydrates, however the aerial part consists mainly of alkaloids. The total polyphenol content obtained in the root part 69.86 mg/gEAG (mg/g of gallic acid) is significantly higher than that in the aerial part 56.79 mg/g EAG. The hydrolysable tannins are the predominant polyphenols of the root part of Haloxylon scoparium corresponding to 83.87 mg/g EAT (mg/g of tannic acid). The antioxidant activity of the various extracts obtained is evaluated by two methods: the DPPH (1,1-diphenyl-2-picryl hydrazyl) free radical scavenging test and the ferric reducing antioxidant power (FRAP). The examination of the inhibitory concentration values shows that the butanolic extract of the root part is the most active with values of IC₅₀ = 0.06 mg/mL and IC_0.5 = 0.19 mg/mL resp. for the DPPH and FRAP tests. The other extracts also showed a very interesting potential as antioxidants. In the experiment, the researchers used many compounds, for example, Dimethyl decanedioate (cas: 106-79-6Reference of 106-79-6).

Dimethyl decanedioate (cas: 106-79-6) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Reference of 106-79-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design was written by Yeh, Teng-Kuang;Song, Jen-Shin;Chang, Po-Wei;Yu, Jin-Chen;Chang, Chia-Hwa;Liao, Fang-Yu;Tien, Ya-Wen;Kuppusamy, Ramajayam;Li, An-Siou;Chen, Chi-Han;Chen, Chieh-Wen;Lin, Li-Mei;Chang, Hsin-Huei;Huang, Chih-Hsiang;Yao, Jau-Ying;Wu, Mine-Hsine;Peng, Yi-Hui;Hsueh, Ching-Cheng;Hsiao, Wen-Chi;Chen, Pei-Husan;Lin, Chin-Yu;Hsieh, Su-Huei;Shih, Chuan;Hung, Ming-Shiu;Wu, Su-Ying;Kuo, Ching-Chuan;Ueng, Shau-Hua. And the article was included in European Journal of Medicinal Chemistry in 2022.Product Details of 16413-26-6 This article mentions the following:

Indoleamine 2,3-dioxygenase-1 (IDO1) is a potential target for the next generation of cancer immunotherapies. We describe the development of two series of IDO1 inhibitors incorporating a N-hydroxy-thiophene-carboximidamide core generated by knowledge-based drug design. Structural modifications to improve the cellular activity and pharmacokinetic (PK) properties of the compounds synthesized, including extension of the side chain of the N-hydroxythiophene-2-carboximidamide core, resulted in compound 27a, a potent IDO1 inhibitor which demonstrated significant (51%) in vivo target inhibition on IDO1 in a human SK-OV-3 ovarian xenograft tumor mouse model. This strategy is expected to be applicable to the discovery of addnl. IDO1 inhibitors for the treatment of other diseases susceptible to modulation of IDO1. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Product Details of 16413-26-6).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Product Details of 16413-26-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics