Month: February 2023

Identification of Key Aroma Compounds in Cranberry Juices as Influenced by Vinification was written by Zhang, Jingying;Kilmartin, Paul A.;Peng, Yaoyao;Chen, Xiao;Quek, Siew-Young. And the article was included in Journal of Agricultural and Food Chemistry in 2020.HPLC of Formula: 868-57-5 This article mentions the following:

This study aimed to identify the key aroma-active volatiles in cranberry wines through three vinification methods (White, Red and Thermo) using GC-MS/O to identify the important aroma compounds A total of 70 compounds were detected, with 67 in wines and 61 in juices. The esters was the most diversified class, while alcs. and acids were the most abundant, especially 3-methylbutanol, methylbutyric acid, and benzoic acid. The volatile profiles of cranberry wines are distinctive from their source juices. Most alcs., esters, and acids are fermentation-derived, while terpenes, phenols, aldehydes and ketones are varietal. The Red vinification retained the most varietal volatiles from the must, while the White and Thermo vinifications produced more volatiles during fermentation Thermovinification reduced the yield of benzoic acid and its derivatives after fermentation Olfactory anal. identified 47 aroma-active compounds, among which 41 were considered as the major aroma contributors (Et benzoate had the highest modified detection frequency). In the experiment, the researchers used many compounds, for example, Methyl2-methylbutyrate (cas: 868-57-5HPLC of Formula: 868-57-5).

Methyl2-methylbutyrate (cas: 868-57-5) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.HPLC of Formula: 868-57-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The migration of NIAS from ethylene-vinyl acetate corks and their identification using gas chromatography mass spectrometry and liquid chromatography ion mobility quadrupole time-of-flight mass spectrometry was written by Vera, Paula;Canellas, Elena;Nerin, Cristina;Dreolin, Nicola;Goshawk, Jeff. And the article was included in Food Chemistry in 2022.Category: esters-buliding-blocks This article mentions the following:

An exhaustive migration study of eight corks, made of ethylene-vinyl acetate, was carried out to identify any non-volatile and volatile compounds using an untargeted approach. The challenge associated with the structural elucidation of unknowns was undertaken using both ultra-high-performance liquid chromatog. coupled to an ion-mobility separation quadrupole-time of flight mass spectrometer and gas chromatog. mass spectrometry. A total of fifty compounds were observed to migrate from the corks, and among these additives such as antioxidants (Bu 4-hydroxybenzoate, Irganox 1010, Irganox 1075, Irgafos 168 and BHT) or lubricants (EBO and octadecanamide, N,N-1,2-ethanediylbis-) were identified. A high proportion (84%) of the detected compounds was non-intentionally added substances (NIAS), and included several cyclic oligomers with different chain sequences. NIAS, such as 2,6-bis(1,1-dimethylethyl)-4-Et and 7,9-ditert-butyl-1-oxaspiro[4.5]deca-6,9-diene-2,8-dione, break-down products, including hexa-, hepta- and nonadecanamide, N,N-1,2-ethanediylbis-, and oxidation products were also identified. One cork was found to be unsuitable for use as a food contact material. In the experiment, the researchers used many compounds, for example, 2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8Category: esters-buliding-blocks).

2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Experimental determination and theoretical correlation for the solubilities of dicarboxylic acid esters in supercritical carbon dioxide was written by Narayan, Ram C.;Dev, Jacob Varun;Madras, Giridhar. And the article was included in Journal of Supercritical Fluids in 2015.Application of 106-79-6 This article mentions the following:

The synthesis of high mol. weight esters such as bis (2-ethylhexyl) sebacate is of significance for its use as a lubricant. This ester is synthesized by the transesterification of di-Me sebacate with 2-ethylhexanol. Therefore, the solubilities of bis (2-ethylhexyl) sebacate and di-Me sebacate were determined at 308-328 K at pressures of 10-18 MPa in supercritical carbon dioxide. The solubility of di-Me sebacate was always higher than bis (2-ethylhexyl) sebacate at a given temperature and pressure. The Mendez-Teja model was used to verify the self-consistency of data. Further, a new semi-empirical model with three parameters was developed using the solution theory coupled with Wilson activity coefficient This model was used to correlate the exptl. data of this work and solubilities of many high mol. weight esters reported in the literature. In the experiment, the researchers used many compounds, for example, Dimethyl decanedioate (cas: 106-79-6Application of 106-79-6).

Dimethyl decanedioate (cas: 106-79-6) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Application of 106-79-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Effects of cigarette filter design on release behavior of monomer flavor in breakable capsule was written by Gu, Junping;Tao, Hong;Wang, Junxia;Chen, Senlin;Ouyang, Lusi;Lin, Baomin;Lu, Jiajian. And the article was included in Yancao Keji in 2021.HPLC of Formula: 659-70-1 This article mentions the following:

In order to investigate the influences of cigarette filter design on the release of monomer flavor components in breakable capsules, the effects of capsule location in filter and filter ventilation on the transfer rates and puff-by-puff releases of 40 representative monomer flavor components in mainstream cigarette smoke were analyzed. The results showed that: 1) Capsule location in filter and filter ventilation levels significantly affected the transfer rates of the aroma components. The transfer rates of the monomer aroma components were higher when the capsule was planted at 6 mm to the mouth end as compared to those at 18 mm, or when the filter was unventilated. With the increase of the mol. weight of flavor compound, the transfer rate ratios between the capsule planted at 6 mm and that at 18 mm of the same component in alc., ketone and ester homologues presented different variation trends. The transfer rate ratios when the filter was unventilated to that of ventilated of the same component in these homologues deceased. 2) The puff-by-puff releases and the puff-by-puff releases per unit TPM of monomer aroma components were higher when the capsule was planted at 6 mm than at 18 mm. The puff-by-puff releases were higher and the puff-by-puff releases per unit TPM were lower when the filter was unventilated than ventilated. 3) The releases of those aroma components with a lower b.p., such as Et hexanoate, Et heptanoate, 2-heptanone, 2-octanone and 1-pentanol, increased significantly at the fourth and fifth puffs. In the experiment, the researchers used many compounds, for example, Isopentyl 3-methylbutanoate (cas: 659-70-1HPLC of Formula: 659-70-1).

Isopentyl 3-methylbutanoate (cas: 659-70-1) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.HPLC of Formula: 659-70-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Structure-Guided Design of Novel, Potent, and Selective Macrocyclic Plasma Kallikrein Inhibitors was written by Li, Zhe;Partridge, James;Silva-Garcia, Abel;Rademacher, Peter;Betz, Andreas;Xu, Qing;Sham, Hing;Hu, Yunjin;Shan, Yuqing;Liu, Bin;Zhang, Ying;Shi, Haijuan;Xu, Qiong;Ma, Xubo;Zhang, Li. And the article was included in ACS Medicinal Chemistry Letters in 2017.Category: esters-buliding-blocks This article mentions the following:

A series of macrocyclic analogs were designed and synthesized based on the cocrystal structure of small mol. plasma kallikrein (pKal) inhibitor, I, with the pKal protease domain. This led to the discovery of a potent macrocyclic pKal inhibitor II, with an IC₅₀ of 2 nM for one olefinic isomer and 42.3 nM for the other olefinic isomer. In the experiment, the researchers used many compounds, for example, Methyl 2-methoxy-4-methylbenzoate (cas: 81245-24-1Category: esters-buliding-blocks).

Methyl 2-methoxy-4-methylbenzoate (cas: 81245-24-1) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Vapor Pressures and Enthalpies of Vaporization of a Series of the Symmetric Linear n-Alkyl Esters of Dicarboxylic Acids was written by Lipp, Svetlana V.;Krasnykh, Eugenii L.;Verevkin, Sergey P.. And the article was included in Journal of Chemical & Engineering Data in 2011.Electric Literature of C11H20O4 This article mentions the following:

Vapor pressures and the molar enthalpies of vaporization of the linear aliphatic alkyl esters of dicarboxylic acids R-CO₂-(CH₂)_n-CO₂-R with n = (0 to 4) with R = C₂H₅, n-C₃H₇, and n-C₄H₉ were determined using the transpiration method. A linear correlation of enthalpies of vaporization (at T = 298.15 K) of the esters with the number n and with Kovat’s indexes was found, proving the internal consistency of measured data. In the experiment, the researchers used many compounds, for example, malonic acid dibutyl ester (cas: 1190-39-2Electric Literature of C11H20O4).

malonic acid dibutyl ester (cas: 1190-39-2) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Electric Literature of C11H20O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tandem catalytic oxidative deacetylation of acetoacetic esters and heteroaromatic cyclizations was written by Ju, Yeming;Miao, Di;Yu, Ruiyang;Koo, Sangho. And the article was included in Organic & Biomolecular Chemistry in 2015.Synthetic Route of C10H13NO2 This article mentions the following:

One pot syntheses of furan, thiophene, and pyrrole were accomplished by oxidative deacetylation using Mn(III)/Co(II) catalysts and the Paal-Knorr reaction from 1,5-dicarbonyl compounds, which are prepared from the conjugate addition of Et acetoacetate to α,β-unsaturated carbonyl compounds The oxidative deacetylation and reductive cyclization of β-ketoesters derived from Et acetoacetate and o-nitrobenzyl bromides efficiently produced diversely substituted indoles. In the experiment, the researchers used many compounds, for example, Ethyl 3-amino-4-methylbenzoate (cas: 41191-92-8Synthetic Route of C10H13NO2).

Ethyl 3-amino-4-methylbenzoate (cas: 41191-92-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Synthetic Route of C10H13NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Biomimetic Asymmetric Reduction of Tetrasubstituted Olefin 2,3-Disubstituted Inden-1-ones with Chiral and Regenerable NAD(P)H Model CYNAM was written by Zhu, Zhou-Hao;Ding, Yi-Xuan;Wu, Bo;Zhou, Yong-Gui. And the article was included in Organic Letters in 2021.Quality Control of malonic acid dibutyl ester This article mentions the following:

Because of the formidable development of the asym. reduction of tetrasubstituted olefins, an effective method is in urgent demand. Herein, through the biomimetic protocol of the coenzyme NAD(P)H, the reduction of tetrasubstituted olefin 2,3-substituted 1H-inden-1-ones has been successfully realized with the catalytic chiral NAD(P)H model CYNAM, which is hard to bring about via the common rhodium or iridium-based catalytic system, producing the corresponding products in good yield (up to 98%) with good enantioselectivity (up to 99% ee). Furthermore, the chiral bioactive mol. can be concisely synthesized from the reduced product. In the experiment, the researchers used many compounds, for example, malonic acid dibutyl ester (cas: 1190-39-2Quality Control of malonic acid dibutyl ester).

malonic acid dibutyl ester (cas: 1190-39-2) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Quality Control of malonic acid dibutyl ester

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Insights into crucial odourants dominating the characteristic flavour of citrus-white teas prepared from citrus reticulata Blanco ‘Chachiensis’ and Camellia sinensis ‘Fudingdabai’ was written by Wang, Jiatong;Shi, Jiang;Zhu, Yin;Ma, Wanjun;Yan, Han;Shao, Chenyang;Wang, Mengqi;Zhang, Yue;Peng, Qunhua;Chen, Yuqiong;Lin, Zhi. And the article was included in Food Chemistry in 2022.Synthetic Route of C10H18O2 This article mentions the following:

Citrus-white teas (CWs), which possess a balanced flavor of tea and citrus, are becoming more popular worldwide; however, their characteristic flavor and odourants received limited research. Volatile components of two types of CWs prepared from Citrus reticulata Blanco’Chachiensis’ and Camellia sinensis ‘Fudingdabai’ were comprehensively investigated using a combination of stir bar sorptive extraction and gas chromatog.-mass spectrometry (GC-MS). Ninety-nine crucial odourants in the CWs were quantified by applying GC-olfactometry/MS, significant differences were compared, and their odor activity values (OAVs) were calculated Twenty-two odourants (in total 2628.09 and 1131.18 mg/kg resp.) were further confirmed as traditional CW (CW-A) and innovated CW (CW-B) characteristic flavor crucial contributors which all possessed > 1 OAVs, particularly limonene (72919 in CW-A) and trans-β-ionone (138953 in CW-B). The unravelling of CWs aroma composition will greatly expanding our understanding of tea aroma chem. and the potential aroma interactions will offer insights into tea blending technologies. In the experiment, the researchers used many compounds, for example, 5-Hexyldihydrofuran-2(3H)-one (cas: 706-14-9Synthetic Route of C10H18O2).

5-Hexyldihydrofuran-2(3H)-one (cas: 706-14-9) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Synthetic Route of C10H18O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Discovery of imidazopyridine derivatives as novel c-Met kinase inhibitors: Synthesis, SAR study, and biological activity was written by Yang, Yifei;Zhang, Yuan;Yang, Ling Yun;Zhao, Leilei;Si, Lianghui;Zhang, Huibin;Liu, Qingsong;Zhou, Jinpei. And the article was included in Bioorganic Chemistry in 2017.Recommanded Product: 14667-47-1 This article mentions the following:

Receptor tyrosine kinase c-Met acts as an alternative angiogenic pathway in the process and contents of cancers. A series of imidazopyridine derivatives were designed and synthesized according to the established docking studies as possible c-Met inhibitors. Most of these imidazopyridine derivatives displayed nanomolar potency against c-Met in both biochem. enzymic screens and cellular pharmacol. studies. Especially, compound 7 g exhibited the most inhibitory activity against c-Met with IC₅₀ of 53.4 nM and 253 nM in enzymic and cellular level, resp. Following that, the compound 7 g was docked into the protein of c-Met and the structure-activity relationship was analyzed in detail. These findings indicated that the novel imidazopyridine derivative compound 7 g was a potential c-Met inhibitor deserving further investigation for cancer treatment. In the experiment, the researchers used many compounds, for example, Methyl 2-aminonicotinate (cas: 14667-47-1Recommanded Product: 14667-47-1).

Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Recommanded Product: 14667-47-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics