Month: February 2023

Identification of aroma compounds in a commonly prescribed oral nutritional supplement and associated changes in olfactory abilities with human ageing was written by Lester, Sophie;Cornacchia, Leonardo;Corbier, Camille;Taylor, Moira A.;Ayed, Charfedinne;Yang, Ni;Lim, Mui;Linforth, Rob;Fisk, Ian. And the article was included in Scientific Reports in 2021.COA of Formula: C10H20O2 This article mentions the following:

Undernutrition is prevalent in the older adult population. Oral nutritional supplements (ONS) are a clin. effective nutritional intervention, however, patient acceptance of ONS can be limited by their palatability. While sensory attributes such as sweetness and mouthfeel have been investigated, the contribution made by aroma to the perceived flavor of ONS has not been studied. Firstly, this research aimed to identify the aroma active compounds within a commonly prescribed ONS using estimated odor activity values (OAV) and gas chromatog. olfactometry mass spectrometry (GC-O-MS). Secondly, age related differences in olfactory detection were explored. Eight aroma active compounds were identified within the ONS, including diacetyl (sweet), isoamyl acetate (banana), di-Me trisulfide (sulfur) and methanethiol (sulfur). When compared with younger adults (n = 24, 18-44 years), older adults (n = 24, 62-80 years) had higher detection thresholds for all aroma compounds and this was significant for isoamyl acetate (sweet, fruity) and methanethiol (sulfur) (p = 0.01 and p = 0.03, resp.). Thus, a decline in olfactory sensitivity was present in the older subjects included in the study, and this reduced detection sensitivity was aroma specific. Thus, older adults flavor perception of ONS likely depends on the combined effect of product factors (the aroma profile) along with age related consumer factors (the degree of impairment in perception). This is a fundamental study which will aid future research into how the aroma profile, and associated age related impairments in perception, shape the global perception of ONS for nutritionally at risk older individuals. In the experiment, the researchers used many compounds, for example, Isopentyl 3-methylbutanoate (cas: 659-70-1COA of Formula: C10H20O2).

Isopentyl 3-methylbutanoate (cas: 659-70-1) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.COA of Formula: C10H20O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Improved synthesis of 6-[(ethylthio)methyl]-1H-indazole was written by Sirven, Agnes M.;Stefak, Roman;Rapenne, Gwenael. And the article was included in Heterocyclic Communications in 2015.Related Products of 41191-92-8 This article mentions the following:

In the improved synthesis of 6-[(ethylthio)methyl]-1H-indazole, the 1H-indazol-6-ylmethyl methanesulfonate intermediate is replaced by the 6-bromomethyl-1H-indazole, which increases the overall yield (six steps) by a factor of (1H-indazol-6-yl)-methanol. In the experiment, the researchers used many compounds, for example, Ethyl 3-amino-4-methylbenzoate (cas: 41191-92-8Related Products of 41191-92-8).

Ethyl 3-amino-4-methylbenzoate (cas: 41191-92-8) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Related Products of 41191-92-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Practical azidation of 1,3-dicarbonyls was written by Harschneck, Tobias;Hummel, Sara;Kirsch, Stefan F.;Klahn, Philipp. And the article was included in Chemistry – A European Journal in 2012.Related Products of 13669-10-8 This article mentions the following:

An operationally simple, direct azidation of 1,3-dicarbonyl compounds has been developed. The reaction proceeds readily under ambient conditions using sodium azide and an iodine-based oxidant such as I₂ or 2-iodoxybenzoic acid (IBX)-SO₃K/NaI. In particular, the latter method, as a new and well-balanced oxidizing agent, shows excellent functional group tolerance and substrate scope and thus allows access to a variety of tertiary 2-azido and 2,2-bisazido 1,3-dicarbonyl compounds that would be more difficult to access by using traditional methods. Because the azide-containing products easily undergo 1,3-dipolar cycloaddition with alkynes, our report represents a novel route to analogs of sensitive complex mols. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Related Products of 13669-10-8).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Related Products of 13669-10-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sensory and chemical characterization of Chinese bog bilberry wines using Check-all-that-apply method and GC-Quadrupole-MS and GC-Orbitrap-MS analyses was written by Lin, Yanxin;Liu, Yaran;Liu, Shuxun;Kortesniemi, Maaria;Liu, Jiani;Zhu, Baoqing;Laaksonen, Oskar. And the article was included in Food Research International in 2022.Product Details of 118-61-6 This article mentions the following:

The sensory and chem. profiles of com. bog bilberry (BB) wines were investigated using a multi-anal. approach. Sensory test included scaling and check-all-that-apply (CATA) method with questions on liking of BB wine. The sensory data was correlated with their volatile compound profiles determined using gas chromatog. coupled with quadrupole and orbitrap mass spectrometry (GC-Quadrupole/Orbitrap-MS). In general, all BB wines were characterized with “fruity”, “blueberry” and “floral” odors and “sour”, “mouth puckering” and “sweet” flavors. Samples more frequently characterized as “fruity” and “floral” in CATA were preferred by the panelists (n = 93). High relative proportions of o-cymene, p-cymenene, 1-octen-3-one and 3-ethylphenol in a sample (described as “ginger” and “chili”) resulted in a lower liking rating. Similarly, generally disliked sample described with “Chinese herbs” and “licorice” was characterized by compounds 3-methylpentan-1-ol, 1,1,6-trimethyl-1,2-dihydronaphthalene, and 4-vinylphenol. The data will give novel information for berry wine and beverage industry on the quality factors of BB wines linked to higher acceptance. In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxybenzoate (cas: 118-61-6Product Details of 118-61-6).

Ethyl 2-hydroxybenzoate (cas: 118-61-6) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Product Details of 118-61-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Renewable Polyethers via GaBr₃-Catalyzed Reduction of Polyesters was written by Dannecker, Patrick-Kurt;Biermann, Ursula;von Czapiewski, Marc;Metzger, Juergen O.;Meier, Michael A. R.. And the article was included in Angewandte Chemie, International Edition in 2018.Quality Control of Dimethyl decanedioate This article mentions the following:

Herein, a novel approach is reported for the synthesis of medium- and long-chain aliphatic polyethers 2 based on the GaBr₃-catalyzed reduction of polyesters 1 with TMDS as the reducing agent. Thus, various linear and branched aliphatic polyesters 1 were prepared and systematically investigated for this reduction strategy, demonstrating the applicability and versatility of this new polyether synthesis protocol. Medium- and long-chain chain polyethers were obtained from the resp. polyesters without or with minor chain degradation, whereas short-chain polyesters, such as poly-L-lactide 1 i and poly[(R)-3-hydroxybutanoate] 1 j, showed major chain degradation In this way, previously unavailable and uncommon polyethers were obtained and studied. In the experiment, the researchers used many compounds, for example, Dimethyl decanedioate (cas: 106-79-6Quality Control of Dimethyl decanedioate).

Dimethyl decanedioate (cas: 106-79-6) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Quality Control of Dimethyl decanedioate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

N-Iodosuccinimide-promoted Regioselective Selenylation of 4H-Pyrido-[1,2-a]-pyrimidin-4-ones with Diselenides at Room Temperature was written by Guo, Lina;Su, Meiyun;Lv, Junliang;Liu, Wenjie;Wang, Shaohua. And the article was included in Asian Journal of Organic Chemistry in 2021.Application In Synthesis of Ethyl 3-oxo-3-(m-tolyl)propanoate This article mentions the following:

A novel and efficient approach for the regioselective selenylation of 4H-pyrido-[1,2-a]-pyrimidin-4-ones with diselenides at room temperature was developed. This procedure was catalyzed by N-iodosuccinimide under metal-free conditions with a broad range of substrate scopes and affords C3 selenylation products in good to excellent yields. Furthermore, the sulfenylation with di-Ph disulfides and 4-methylbenzenethiol in this transformation was successful. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9Application In Synthesis of Ethyl 3-oxo-3-(m-tolyl)propanoate).

Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Application In Synthesis of Ethyl 3-oxo-3-(m-tolyl)propanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis, characterization and antimicrobial activity of azetidine derivatives was written by Choudhary, Shweta;Dubey, Archana;Chaturvedi, Prerna;Birle, Rekha. And the article was included in International Journal of Pharmacy and Life Sciences in 2021.Recommanded Product: Ethyl 2-hydroxybenzoate This article mentions the following:

In present study azetidine derivatives were synthesized and microbial activity of different derivatives were checked with various microbial stain. Various intermediates was synthesized and characterized in between time to time by chromatog. and special methods. Substituted salicylic acid and sulfuric acid were starting material and finally formed2-Hydroxy -N-2-oxa-4-phenylazet-1(2H)0ylbenzamide(D), while in the intermediate steps(A) Ethylsalicylate react with hydrazine hydrate to get,(B) Salicyl Hydrazide, and this (B) compound reflux with sulfuric acid to get (C) 2 -hydroxy-N-[(Z)- phenylmethylidene]benzohydrazide. Azetidine derivatives have been synthesized from Schiff base of the corresponding hydrazine by using ethanol with reflex. The structure of the entire synthesized compound was established on the basis of element, chromatog. and spectral anal. The synthesized compound was evaluated for their antimicrobial activity. Most active be against Staphylococcus. In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxybenzoate (cas: 118-61-6Recommanded Product: Ethyl 2-hydroxybenzoate).

Ethyl 2-hydroxybenzoate (cas: 118-61-6) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Recommanded Product: Ethyl 2-hydroxybenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

High Performance Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry Based Metabolomic Detection of Non-Volatile Components of Different Chemotype of Cinnamomum camphora was written by Jinqiang Yang;Lin, Qin;Fan, Luyi;Yang, Nianyun. And the article was included in Journal of Analytical Chemistry in 2020.Application In Synthesis of Ethyl 2-hydroxybenzoate This article mentions the following:

A liquid chromatog.-quadrupole time-of-flight mass spectrometry (LC-QTOF/MS) based plant metabolomics approach was established to investigate the metabolic profiles of the Cinnamomum camphora leaves of four different areas. The LC-QTOF/MS data were subjected to principal component anal. (PCA) and orthogonal partial least squared discrimination anal. (OPLS-DA) to find the potential characteristic components of C. camphora leaves from the four areas in a quick way. C. camphora leaves from different areas could be separated into four different groups chem. according to the PCA scores. The chem. constituents in C. camphora leaves from four areas were obviously different. The potential markers were identified by comparison with the reference compounds or were tentatively assigned by matching the retention time, empirical mol. formula and fragment ions with those of the published compounds of C. camphora leaves. The proposed anal. method is fast, accurate and reliable for differentiating C. camphora leaves from different areas. Moreover, this study supplied a new method for the quality evaluation of other medicinal materials. In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxybenzoate (cas: 118-61-6Application In Synthesis of Ethyl 2-hydroxybenzoate).

Ethyl 2-hydroxybenzoate (cas: 118-61-6) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Application In Synthesis of Ethyl 2-hydroxybenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hindered phenolic antioxidants as heat-oxygen stabilizers for HDPE was written by Wang, Yuru;Ren, He;Yan, Yibin;He, Shuyan;Wu, Shuang;Zhao, Qian. And the article was included in Polymers and Polymer Composites in 2021.Related Products of 6683-19-8 This article mentions the following:

The effects of four hindered phenolic antioxidants in the short-term heat-oxygen stability of High-D. Polyethylene (HDPE) was evaluated by the Melt Flow Rate (MFR) and Oxidation Induction Time (OIT) analyses. The results showed that Irganox 1330 and Irganox 1010 had more excellent processing property and oxidation resistance behavior in HDPE than Irganox 1024 and Irganox 3114. The OIT values of HDPE with Irganox 1330 and Irganox 1010 were up to 97.25 min and 89.73 min resp. The long-term accelerated heat-oxygen stability tests of HDPE containing hindered phenolic antioxidants were carried out at 110°C in deionized water pressurized with pure oxygen at a pressure of 10 MPa. The characterization of the long-term heat-oxygen stability was performed by Fourier Transform IR (FTIR), Differential Scanning Calorimetry (DSC) and tensile testing. However, the results exhibited that the aging resistance of HDPE containing Irganox 1010 was inferior to that of HDPE containing Irganox 1024 and Irganox 3114, which is quite contrary to their short-term effect on HDPE stabilization. It may be speculated that the ester groups of Irganox 1010 undergo hydrolysis during the long-term heat-oxygen stability tests, leading to the formation of 3-(3,5-ditert-butyl-4-hydroxy-phenyl) propanoic acid and pentaerythritol. In the experiment, the researchers used many compounds, for example, 2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8Related Products of 6683-19-8).

2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Related Products of 6683-19-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Development of selective tight-binding inhibitors of leukotriene A₄ hydrolase was written by Yuan, Wei;Munoz, Benito;Wong, Chi Huey;Haeggstroem, Jesper Z.;Wetterholm, Anders;Samuelsson, Bengt. And the article was included in Journal of Medicinal Chemistry in 1993.Application In Synthesis of (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate This article mentions the following:

A systematic study on the enzyme specificity and the inhibition of leukotriene A₄ hydrolase amidase activity with more than 30 synthetic inhibitors has led to the development of α-keto-β-amino ester I (R = COCO₂CH₂Ph) and thioamine I (R = CH₂SH) as tight-binding, competitive type transition-state analog inhibitors of the aminopeptidase activity, with K_i values of 46 and 18 nM, resp. Both compounds also inhibit the epoxide hydrolase activity, with the IC₅₀ values of 1 μM and 0.1 μM, resp. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9Application In Synthesis of (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate).

(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Application In Synthesis of (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics