Synthesis of physostigmine analogues and evaluation of their anticholinesterase activities was written by Zhan, Zha-Jun;Bian, Hong-Ling;Wang, Jian-Wei;Shan, Wei-Guang. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Product Details of 16413-26-6 This article mentions the following:
A series of physostigmine analogs I (R = Ph, 3-ClC6H4, 1-naphthyl, cyclohexyl, etc.) were prepared and evaluated for cholinesterase inhibition activities, including acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Most of them showed potent inhibition activities against AChE, in which compound I (R = cyclohexyl) especially exhibited significantly higher selectivity over BChE than phenserine, a compound currently on clin. trial. Discussion about the relationships between structure and activity of these derivatives was also presented. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Product Details of 16413-26-6).
3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Product Details of 16413-26-6
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics