A facile semi-synthetic approach towards halogen-substituted aminobenzoic acid analogues of platensimycin was written by Qiu, Lin;Tian, Kai;Pan, Jian;Jiang, Lin;Yang, Hu;Zhu, Xiangcheng;Shen, Ben;Duan, Yanwen;Huang, Yong. And the article was included in Tetrahedron in 2017.Safety of Methyl 3-amino-2-fluorobenzoate This article mentions the following:
Platensimycin (PTM), produced by several strains of Streptomyces platensis, is a promising drug lead for infectious diseases and diabetes. The recent pilot-scale production of PTM from S. platensis SB12026 has set the stage for the facile semi-synthesis of a focused library of PTM analogs. In this study, gram-quantity of platensic acid (PTMA) was prepared by the sulfuric acid-catalyzed ethanolysis of PTM, followed by a mild hydrolysis in aqueous lithium hydroxide. Three PTMA esters were also obtained in near quant. yields in a single step, suggesting a facile route to make PTMA aliphatic esters. 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate (HATU)-catalyzed coupling of PTMA and 33 aminobenzoates resulted in the synthesis of 28 substituted aminobenzoate analogs of PTM, among which 26 of them were reported for the first time. Several of the PTM analogs showed weak antibacterial activity against methicillin-resistant Staphylococcus aureus. Our study supported the potential utility to integrate natural product biosynthetic and semi-synthetic approaches for structure diversification. In the experiment, the researchers used many compounds, for example, Methyl 3-amino-2-fluorobenzoate (cas: 1195768-18-3Safety of Methyl 3-amino-2-fluorobenzoate).
Methyl 3-amino-2-fluorobenzoate (cas: 1195768-18-3) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Safety of Methyl 3-amino-2-fluorobenzoate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics