Divergent synthesis of kinase inhibitor derivatives, leading to discovery of selective Gck inhibitors was written by Matsumaru, Takanori;Inai, Makoto;Ishigami, Kana;Iwamatsu, Toshiki;Maita, Hiroshi;Otsuguro, Satoko;Nomura, Takao;Matsuda, Akira;Ichikawa, Satoshi;Sakaitani, Masahiro;Shuto, Satoshi;Maenaka, Katsumi;Kan, Toshiyuki. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2017.Application In Synthesis of Methyl 2-aminonicotinate This article mentions the following:
We accomplished divergent synthesis of potent kinase inhibitor BAY 61-3606 (1, I) and 27 derivatives via conjugation of imidazo[1,2-c]pyrimidine and indole ring compounds with aromatic (including pyridine) derivatives by means of palladium-catalyzed cross-coupling reaction. Spleen tyrosine kinase (Syk) and germinal center kinase (Gck, MAP4K2) inhibition assays showed that some of the synthesized compounds were selective Gck inhibitors. In the experiment, the researchers used many compounds, for example, Methyl 2-aminonicotinate (cas: 14667-47-1Application In Synthesis of Methyl 2-aminonicotinate).
Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Application In Synthesis of Methyl 2-aminonicotinate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics