Lipase immobilization on hyroxypropyl methyl cellulose support and its applications for chemo-selective synthesis of β-amino ester compounds was written by Badgujar, Kirtikumar C.;Bhanage, Bhalchandra M.. And the article was included in Process Biochemistry (Oxford, United Kingdom) in 2016.Category: esters-buliding-blocks This article mentions the following:
The present study carried out the synthesis of β-amino ester compounds using lipase immobilized on hyroxypropyl Me cellulose (HMC) support. Initially various lipases (biocatalysts) from different origins were immobilized and subsequently screened to obtain a robust biocatalyst. The lipase from Pseudomonas fluorescens (PFL) immobilized on HMC displayed the highest lipase activity, protein content and retention of activity. Phys. and biochem. characterization verified immobilization of lipase PFL on the HMC support. This immobilized biocatalyst HMC:PFL (3.5:1) was successfully applied for the practical biocatalytic synthesis of a variety of β-amino esters. Eight reaction parameters were optimized in detail to achieve the maximum yield and chemo-selectivity. The developed biocatalytic protocol was successfully applied to synthesize different industrially important β-amino esters compounds (21 substrates) with an excellent yield (>90%) and remarkable chemo selectivity (>94%). Interestingly, the immobilized HMC:PFL lipase showed 2.1-2.5 fold higher bio-catalytic activity and five times recyclability as compared to the free PFL. A plausible mechanism for lipase catalyzed synthesis of β-amino ester compounds was also proposed. In the experiment, the researchers used many compounds, for example, Methyl 3-(cyclopentylamino)propanoate (cas: 754125-43-4Category: esters-buliding-blocks).
Methyl 3-(cyclopentylamino)propanoate (cas: 754125-43-4) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Category: esters-buliding-blocks
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics