Interaction of phenolic acids and their derivatives with human serum albumin structure-affinity relationships and effects on antioxidant activity was written by Zhang, Yunyue;Wu, Simin;Qin, Yinghui;Liu, Jiaxin;Liu, Jingwen;Wang, Qingyu;Ren, Fazheng;Zhang, Hao. And the article was included in Food Chemistry in 2018.Product Details of 81245-24-1 This article mentions the following:
In this study, 111 phenolic acids and their derivatives were chosen to investigate their structure-affinity relationships when binding to human serum albumin (HSA), and effects on their antioxidant activity. A comprehensive math. model was employed to calculate the binding constants, using a fluorescence quenching method, and this was corrected for the inner-filter effect to improve accuracy. We found that a hydroxy group at the 2-position of the benzene ring exerted a pos. effect on the affinities, while a 4-hydroxy substituent had a neg. influence. Both methylation of the hydroxy groups and replacing the hydroxy groups with Me groups at the 3- and 4-positions of the benzene ring enhanced the binding affinities. Hydrophobic force and hydrogen bonding were binding forces for the phenolic acids, and their Me esters, resp. The antioxidant activity of the HSA-phenolic acid interaction compounds was higher than that of the phenolic acids alone. In the experiment, the researchers used many compounds, for example, Methyl 2-methoxy-4-methylbenzoate (cas: 81245-24-1Product Details of 81245-24-1).
Methyl 2-methoxy-4-methylbenzoate (cas: 81245-24-1) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Product Details of 81245-24-1
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics