Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design was written by Yeh, Teng-Kuang;Song, Jen-Shin;Chang, Po-Wei;Yu, Jin-Chen;Chang, Chia-Hwa;Liao, Fang-Yu;Tien, Ya-Wen;Kuppusamy, Ramajayam;Li, An-Siou;Chen, Chi-Han;Chen, Chieh-Wen;Lin, Li-Mei;Chang, Hsin-Huei;Huang, Chih-Hsiang;Yao, Jau-Ying;Wu, Mine-Hsine;Peng, Yi-Hui;Hsueh, Ching-Cheng;Hsiao, Wen-Chi;Chen, Pei-Husan;Lin, Chin-Yu;Hsieh, Su-Huei;Shih, Chuan;Hung, Ming-Shiu;Wu, Su-Ying;Kuo, Ching-Chuan;Ueng, Shau-Hua. And the article was included in European Journal of Medicinal Chemistry in 2022.Product Details of 16413-26-6 This article mentions the following:
Indoleamine 2,3-dioxygenase-1 (IDO1) is a potential target for the next generation of cancer immunotherapies. We describe the development of two series of IDO1 inhibitors incorporating a N-hydroxy-thiophene-carboximidamide core generated by knowledge-based drug design. Structural modifications to improve the cellular activity and pharmacokinetic (PK) properties of the compounds synthesized, including extension of the side chain of the N-hydroxythiophene-2-carboximidamide core, resulted in compound 27a, a potent IDO1 inhibitor which demonstrated significant (51%) in vivo target inhibition on IDO1 in a human SK-OV-3 ovarian xenograft tumor mouse model. This strategy is expected to be applicable to the discovery of addnl. IDO1 inhibitors for the treatment of other diseases susceptible to modulation of IDO1. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Product Details of 16413-26-6).
3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Product Details of 16413-26-6
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