2-Aminonicotinic Acid 1-Oxides Are Chemically Stable Inhibitors of Quinolinic Acid Synthesis in the Mammalian Brain: A Step toward New Antiexcitotoxic Agents was written by Vallerini, Gian Paolo;Amori, Laura;Beato, Claudia;Tararina, Margarita;Wang, Xiao-Dan;Schwarcz, Robert;Costantino, Gabriele. And the article was included in Journal of Medicinal Chemistry in 2013.Reference of 14667-47-1 This article mentions the following:
3-Hydroxyanthranilic acid 3,4-dioxygenase (3-HAO) is the enzyme responsible for the production of the neurotoxic tryptophan metabolite quinolinic acid (QUIN). Elevated brain levels of QUIN are observed in several neurodegenerative diseases, but pharmacol. investigation on its role in the pathogenesis of these conditions is difficult because only one class of substrate-analog 3-HAO inhibitors, with poor chem. stability, has been reported so far. Here we describe the design, synthesis, and biol. evaluation of a novel class of chem. stable inhibitors based on the 2-aminonicotinic acid 1-oxide nucleus. After the preliminary in vitro evaluation of newly synthesized compounds using brain tissue homogenate, we selected the most active inhibitor and showed its ability to acutely reduce the production of QUIN in the rat brain in vivo. These findings provide a novel pharmacol. tool for the study of the mechanisms underlying the onset and propagation of neurodegenerative diseases. In the experiment, the researchers used many compounds, for example, Methyl 2-aminonicotinate (cas: 14667-47-1Reference of 14667-47-1).
Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Reference of 14667-47-1
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics