Small Molecule Inhibitors of Regulators of G Protein Signaling (RGS) Proteins was written by Turner, Emma M.;Blazer, Levi L.;Neubig, Richard R.;Husbands, Stephen M.. And the article was included in ACS Medicinal Chemistry Letters in 2012.Application of 2740-88-7 This article mentions the following:
Recently, regulators of G protein signaling (RGS) proteins have emerged as potential therapeutic targets since they provide an alternative method of modulating the activity of G protein-coupled receptors, the target of so many drugs. Inhibitors of RGS proteins must block a protein-protein interaction (RGS-G浼? but also be cell and, depending on the therapeutic target, blood-brain barrier permeable. A lead compound (1a) was identified as an inhibitor of RGS4 in a screening assay, and this has now been optimized for activity, selectivity, and solubility The newly developed ligands (11b and 13) display substantial selectivity over the closely related RGS8 protein, lack the off-target calcium mobilization activity of the lead 1a, and have excellent aqueous solubility They are currently being evaluated in vivo in rodent models of depression. In the experiment, the researchers used many compounds, for example, 4-Fluorobenzylisothiocyanate (cas: 2740-88-7Application of 2740-88-7).
4-Fluorobenzylisothiocyanate (cas: 2740-88-7) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Application of 2740-88-7
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