Phenyl bioisosteres in medicinal chemistry: discovery of novel 绾?secretase modulators as a potential treatment for Alzheimer閳ョ灚 disease was written by Ratni, H.;Baumann, K.;Bellotti, P.;Cook, X. A.;Green, L. G.;Luebbers, T.;Reutlinger, M.;Stepan, A. F.;Vifian, W.. And the article was included in RSC Medicinal Chemistry in 2021.Safety of Methyl 4-aminobicyclo[2.2.2]octane-1-carboxylate This article mentions the following:
Ph rings are one of the most prevalent structural moieties in active pharmaceutical ingredients, even if they often contribute to poor physico-chem. properties. Herein, we propose the use of a bridged piperidine (BP) moiety as a Ph bioisostere, which could also be seen as a superior Ph alternative as it led to strongly improved drug like properties, in terms of solubility and lipophilicity. Addnl., this BP moiety compares favorably to the recently reported saturated Ph bioisosteres. We applied this concept to our 绾?secretase modulator (GSM) project for the potential treatment of Alzheimer閳ョ灚 disease delivering clin. candidates. In the experiment, the researchers used many compounds, for example, Methyl 4-aminobicyclo[2.2.2]octane-1-carboxylate (cas: 135908-33-7Safety of Methyl 4-aminobicyclo[2.2.2]octane-1-carboxylate).
Methyl 4-aminobicyclo[2.2.2]octane-1-carboxylate (cas: 135908-33-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Safety of Methyl 4-aminobicyclo[2.2.2]octane-1-carboxylate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics