Distinct Spacing Between Anionic Groups: An Essential Chemical Determinant for Achieving Thiophene-Based Ligands to Distinguish 灏?Amyloid or Tau Polymorphic Aggregates was written by Klingstedt, Therese;Shirani, Hamid;Mahler, Jasmin;Wegenast-Braun, Bettina M.;Nystroem, Sofie;Goedert, Michel;Jucker, Mathias;Nilsson, K. Peter R.. And the article was included in Chemistry – A European Journal in 2015.HPLC of Formula: 19432-68-9 This article mentions the following:
The accumulation of protein aggregates is associated with many devastating neurodegenerative diseases and the existence of distinct aggregated morphotypes has been suggested to explain the heterogeneous phenotype reported for these diseases. Thus, the development of mol. probes able to distinguish such morphotypes is essential. We report an anionic tetrameric oligothiophene compound that can be utilized for spectral assignment of different morphotypes of 灏?amyloid or tau aggregates present in transgenic mice at distinct ages. The ability of the ligand to spectrally distinguish between the aggregated morphotypes was reduced when the spacing between the anionic substituents along the conjugated thiophene backbone was altered, which verified that specific mol. interactions between the ligand and the protein aggregate are necessary to detect aggregate polymorphism. Our findings provide the structural and functional basis for the development of new fluorescent ligands that can distinguish between different morphotypes of protein aggregates. In the experiment, the researchers used many compounds, for example, Methyl 2-thienylacetate (cas: 19432-68-9HPLC of Formula: 19432-68-9).
Methyl 2-thienylacetate (cas: 19432-68-9) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters contain a carbonyl center, which gives rise to 120鎺?C閳ユ弲閳ユ彊 and O閳ユ弲閳ユ彊 angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C閳ユ彊閳ユ弲 bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. HPLC of Formula: 19432-68-9
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics