Design, synthesis and biological evaluation of nuclear receptor-degradation inducers was written by Itoh, Yukihiro;Kitaguchi, Risa;Ishikawa, Minoru;Naito, Mikihiko;Hashimoto, Yuichi. And the article was included in Bioorganic & Medicinal Chemistry in 2011.Quality Control of Methyl 2-methoxy-4-methylbenzoate This article mentions the following:
Compounds that regulate the function(s) of nuclear receptors (NRs) are useful for biol. studies and as candidate therapeutic agents. Most such compounds are agonists or antagonists. We have developed specific protein degradation inducers, which we designated as SNIPERs (Specific and Nongenetic IAPs-dependent Protein ERasers), for selective degradation of target proteins. SNIPERs are hybrid mols. consisting of an appropriate ligand for the protein of interest, coupled to a ligand for inhibitor of apoptosis proteins (IAPs), which target the bound protein for polyubiquitination and proteasomal degradation We considered that protein knockdown with SNIPERs would be a promising alternative approach for modulating NR function. In this study, we designed and synthesized degradation inducers targeting retinoic acid receptor (RAR), estrogen receptor (ER), and androgen receptor (AR). These newly synthesized RAR, ER, and AR SNIPERs, 9, 11, and 13, resp., were confirmed to significantly reduce the levels of the corresponding NRs in live cells. In the experiment, the researchers used many compounds, for example, Methyl 2-methoxy-4-methylbenzoate (cas: 81245-24-1Quality Control of Methyl 2-methoxy-4-methylbenzoate).
Methyl 2-methoxy-4-methylbenzoate (cas: 81245-24-1) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Quality Control of Methyl 2-methoxy-4-methylbenzoate
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