Privileged structure based ligands for melanocortin receptors – Substituted benzylic piperazine derivatives was written by Fisher, Matthew J.;Backer, Ryan T.;Collado, Ivan;De Frutos, Oscar;Husain, Saba;Hsiung, Hansen M.;Kuklish, Steve L.;Mateo, Ana I.;Mullaney, Jeffrey T.;Ornstein, Paul L.;Paredes, Cristina Garcia;O’Brian, Thomas P.;Richardson, Timothy I.;Shah, Jikesh;Zgombick, John M.;Briner, Karin. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2005.Recommanded Product: Ethyl 2-fluorophenylacetate This article mentions the following:
Replacement of the arylpiperazine moiety in I with a variety of substituted benzylic piperazines yields compounds that afford melanocortin receptor 4 (MCR4) activity. Analogs with ortho substitution on the aromatic ring afforded the highest affinity. Resolution of the stereocenter of the benzylic piperazine based privileged structure revealed that the R-enantiomer was more active. In the experiment, the researchers used many compounds, for example, Ethyl 2-fluorophenylacetate (cas: 584-74-7Recommanded Product: Ethyl 2-fluorophenylacetate).
Ethyl 2-fluorophenylacetate (cas: 584-74-7) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Recommanded Product: Ethyl 2-fluorophenylacetate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics