FeCl3-Promoted [3 + 2] Annulations of 绾?Butyrolactone Fused Cyclopropanes with Heterocumulenes was written by Feng, Manli;Yang, Pengfei;Yang, Gaosheng;Chen, Wenlong;Chai, Zhuo. And the article was included in Journal of Organic Chemistry in 2018.Product Details of 2740-88-7 This article mentions the following:
In the presence of FeCl3 in 1,2-dichloroethane, cyclopropane-fused 绾?lactones such as I (R = Me, Et; R1 = Ph, 4-MeC6H4, 4-MeOC6H4, 3-MeOC6H4, 2-MeOC6H4, 4-BrC6H4, 4-ClC6H4, 3-ClC6H4, 2-ClC6H4, 4-O2NC6H4; R2 = Ph, 4-MeC6H4, 4-MeOC6H4, 3-MeOC6H4, 2-MeOC6H4, 4-BrC6H4, 4-O2NC6H4) underwent regio- and diastereoselective cycloadditions with isothiocyanates R3NCS (R3 = Ph, 4-MeC6H4, 2-MeC6H4, 4-MeOC6H4, 3-MeOC6H4, 2-MeOC6H4, 4-ClC6H4, 2-ClC6H4, 4-FC6H4, 4-F3CC6H4, 4-O2NC6H4, 3-O2NC6H4, 2-O2NC6H4, PhCH2, 4-FC6H4CH2, H2C:CHCH2, PhCH2CH2, Bu, cyclohexyl) and carbodiimides R4N:C:NR4 (R4 = cyclohexyl, i-Pr) to yield thioimidate- and amidine-containing 绾?lactones such as II (R = Me, Et; R1 = Ph, 4-MeC6H4, 4-MeOC6H4, 3-MeOC6H4, 2-MeOC6H4, 4-BrC6H4, 4-ClC6H4, 3-ClC6H4, 2-ClC6H4, 4-O2NC6H4; R2 = Ph, 4-MeC6H4, 4-MeOC6H4, 3-MeOC6H4, 2-MeOC6H4, 4-BrC6H4, 4-O2NC6H4; R3 = Ph, 4-MeC6H4, 2-MeC6H4, 4-MeOC6H4, 3-MeOC6H4, 2-MeOC6H4, 4-ClC6H4, 2-ClC6H4, 4-FC6H4, 4-F3CC6H4, 4-O2NC6H4, 3-O2NC6H4, 2-O2NC6H4, PhCH2, 4-FC6H4CH2, H2C:CHCH2, PhCH2CH2, Bu, cyclohexyl) and III (R = Et; R1 = Ph, 4-MeC6H4, 4-MeOC6H4, 3-MeOC6H4, 4-BrC6H4, 4-ClC6H4, 4-O2NC6H4; R2 = Ph, 4-MeC6H4, 4-MeOC6H4, 3-MeOC6H4, 2-MeOC6H4, 4-BrC6H4, 4-O2NC6H4; R4 = cyclohexyl, i-Pr) in 93-99% and 94-99% yields, resp., as single diastereomers. In the experiment, the researchers used many compounds, for example, 4-Fluorobenzylisothiocyanate (cas: 2740-88-7Product Details of 2740-88-7).
4-Fluorobenzylisothiocyanate (cas: 2740-88-7) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Product Details of 2740-88-7
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics