Dipyridyl amines: Potent metabotropic glutamate subtype 5 receptor antagonists was written by Kamenecka, Theodore M.;Bonnefous, Celine;Govek, Steven;Vernier, Jean-Michel;Hutchinson, John;Chung, Janice;Reyes-Manalo, Grace;Anderson, Jeffery J.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2005.Reference of 14667-47-1 This article mentions the following:
Modulation of the metabotropic glutamate subtype 5 (mGluR5) receptor may be useful in the treatment of a variety of central nervous system disorders. Here, the discovery, synthesis, and biol. evaluation of dipyridyl amines as small mol. mGluR5 antagonists, is reported. In the experiment, the researchers used many compounds, for example, Methyl 2-aminonicotinate (cas: 14667-47-1Reference of 14667-47-1).
Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Reference of 14667-47-1
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics