Synthesis and Biological Evaluation of C-5 Methyl Substituted 4-Arylthio and 4-Aryloxy-3-Iodopyridin-2(1H)-one Type Anti-HIV Agents was written by Guillemont, Jerome;Benjahad, Abdellah;Oumouch, Said;Decrane, Laurence;Palandjian, Patrice;Vernier, Daniel;Queguiner, Laurence;Andries, Koen;de Bethune, Marie-Pierre;Hertogs, Kurt;Grierson, David S.;Nguyen, Chi Hung. And the article was included in Journal of Medicinal Chemistry in 2009.Related Products of 173341-02-1 This article mentions the following:
A series of C-5 Me substituted 4-arylthio- and 4-aryloxy-3-iodopyridin-2(1H)-ones, e.g. I (X = O, S; R = SCH2CONHMe, 2-tetrazolyl, 1-imidazolyl, etc.), has been synthesized as new pyridinone analogs for their evaluation as anti-HIV inhibitors. The optimization at the 5-position was developed through an efficient use of the key intermediates 5-ethoxycarbonyl- and 5-cyano-pyridin-2(1H)-ones. Biol. studies revealed that several compounds show potent HIV-1 reverse transcriptase inhibitory properties, for example, I [X = S; R = 1-tetrazolyl, 2-tetrazolyl] are active at 0.6-50 nM against wild type HIV-1 and a panel of major simple/double HIV mutant strains. In the experiment, the researchers used many compounds, for example, tert-Butyl (morpholin-2-ylmethyl)carbamate (cas: 173341-02-1Related Products of 173341-02-1).
tert-Butyl (morpholin-2-ylmethyl)carbamate (cas: 173341-02-1) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Related Products of 173341-02-1
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics