Chiral Iridium Catalysts Bearing Spiro Pyridine-Aminophosphine Ligands Enable Highly Efficient Asymmetric Hydrogenation of β-Aryl β-Ketoesters was written by Xie, Jian-Hua;Liu, Xiao-Yan;Yang, Xiao-Hui;Xie, Jian-Bo;Wang, Li-Xin;Zhou, Qi-Lin. And the article was included in Angewandte Chemie, International Edition in 2012.Synthetic Route of C12H14O3 This article mentions the following:
A highly efficient asym. hydrogenation of β-dicarbonyl compounds, including β-ketoesters, β-ketoamides and β-diketones, catalyzed by iridium complexes with SpiroPAP (spiro pyridine-aminophosphine) ligands is reported. The reaction provides β-hydroxy esters/amides and diols in excellent enantioselectivity (up to 99.8% ee) and extremely high TONs (up to 1230000), which represents the highest level of efficiency in the asym. hydrogenation of β-ketoesters. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9Synthetic Route of C12H14O3).
Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Synthetic Route of C12H14O3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics