Synthesis and 3D quantitative SAR study of quinazoline derivatives containing a 1,3,4-oxadiazole moiety as efficient inhibitors against Xanthomonas axonopodis pv. citri was written by Wang, Xiaobin;Yan, Jinghua;Wang, Mengqi;Liu, Menghan;Zhang, Juping;Chen, Lijuan;Xue, Wei. And the article was included in Molecular Diversity in 2018.Related Products of 587-88-2 This article mentions the following:
A series of quinazoline derivatives containing a 1,3,4-oxadiazole moiety I [R1 = H, 6-Cl, 8-Me; R2 = Ph, 4-ClC6H5, PhOCH2, etc.] were synthesized and evaluated for their antibacterial activities against Xanthomonas axonopodis pv. citri (Xac) and Ralstonia solanacearum (Rs). Antibacterial bioassays indicated that most of target compounds exhibited significant antibacterial activities against Xac and Rs in-vitro. Strikingly, compounds I [R1 = H; R2 = C6H5OCH2, 4-O2NC6H5, 2-MeC6H5CH2, 4-FC6H5CH2, 4-ClC6H5CH2, 4-FC6H5OCH2, 4-ClC6H5OCH2], [R1 = 6-Cl; R2 = C6H5OCH2, 4-O2NC6H5, 2-MeC6H5CH2, 4-FC6H5CH2, 4-ClC6H5CH2, 4-ClC6H5OCH2] and [R1 = 8-Me; R2 = 4-FC6H5CH2, 4-ClC6H5CH2, 4-FC6H5OCH2, 4-ClC6H5OCH2] showed antibacterial activity against Xac, with EC50 values ranging from 14.42 to 38.91 μg/mL, which are better than that of bismerthiazol (39.86 μg/mL). Based on the antibacterial activity against Xac,comparative mol. filed anal. and comparative mol. similarity index anal. models were generated to investigate the structure-activity relationship of title compounds against Xac. The anal. results indicated that the above models exhibited good predictive accuracy and could be used as practical tools for guiding the design and synthesis of more potent quinazoline derivatives containing a 1,3,4-oxadiazole moiety. In the experiment, the researchers used many compounds, for example, Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2Related Products of 587-88-2).
Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Related Products of 587-88-2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics