Parallel synthesis of isatin-based serine protease inhibitors was written by Shuttleworth, Stephen J.;Nasturica, Daniel;Gervais, Christian;Siddiqui, M. Arshad;Rando, Robert F.;Lee, Nola. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2000.Category: esters-buliding-blocks This article mentions the following:
The synthesis of N-functionalized isatins, such as I [R = CH(Me)COC6H4-3-OMe, R1 = Me, R3 = H; R = CH2CONH2, CH2COC6H4-4-Cl, R1 = R3 = H], using parallel, solution synthesis is described. Functionalized polymers were employed as stoichiometric and catalytic reagents as well as purification media. The prepared isatins showed inhibition against a panel of serine proteases, i.e. human chymotrypsin, human leukocyte elastase, and human plasmin. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Category: esters-buliding-blocks).
3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Category: esters-buliding-blocks
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics