Lipase-catalyzed synthesis of polymeric prodrugs of nonsteroidal anti-inflammatory drugs was written by Qian, Xueqi;Wu, Qi;Xu, Fangli;Lin, Xianfu. And the article was included in Journal of Applied Polymer Science in 2013.Formula: C12H22O4 This article mentions the following:
Because of the potential application of prodrugs of nonsteroidal anti-inflammatory drugs (NSAIDs), Candida antarctica lipase B (CAL-B) catalyzed polycondensation of profen-containing diol monomers and diesters were designed to prepare a series of biodegradable polymeric prodrugs composed of NSAID branches and poly(amide-co-ester) backbone. The structure of the products was confirmed by Fourier transform IR spectroscopy, NMR, and gel permeation chromatog. (GPC). The reaction conditions of polymerization, such as the enzyme source, amount of catalyst, and temperature, were optimized. The mol. weights of resultant copolymers were 2170-13,270 g/mol, with corresponding polydispersities from 1.17 to 2.4. The copolymers had relatively high drug loadings of 44.7-59.7 wt % because every repeat unit contained one drug mol. The strategy of enzymic polymerization appeared to be quite general and accommodated a large number of comonomer substrates with various chain lengths and substituents. The optically pure (R)-naproxen monomer was demonstratively incorporated into the corresponding copolymers with the developed synthesis strategy. The in vitro study showed that the polyester could release the drug effectively under physiol. conditions with enzyme, which indicated that the obtained product could be a promising prodrug for extending pharmacol. effects by delayed drug release. With GPC anal., we confirmed that the prodrug was completely degradable in aqueous solution The attractive features of the copolymer were its high drug loading, biodegradability, and biocompatibility. The high tolerance of the CAL-B toward drug groups, as described in this article, provides a new route for synthesizing polymeric drugs with potential biomedical applications in mild conditions and for reducing environmental impact. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2012. In the experiment, the researchers used many compounds, for example, Dimethyl decanedioate (cas: 106-79-6Formula: C12H22O4).
Dimethyl decanedioate (cas: 106-79-6) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Formula: C12H22O4
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics