The Search for Histamine H4 Receptor Ligands with Anticancer Activity among Novel (Thio)urea Derivatives was written by Dominguez-Alvarez, Enrique;Lazewska, Dorota;Szabo, Zsanett;Hagenow, Stefanie;Reiner, David;Gajdacs, Mario;Spengler, Gabriella;Stark, Holger;Handzlik, Jadwiga;Kiec-Kononowicz, Katarzyna. And the article was included in ChemistrySelect in 2019.HPLC of Formula: 16413-26-6 This article mentions the following:
A series of (thio)urea-containing compounds I [R = Ph, Bn, 4-PhC6H4, etc.; X = O, S] and II [A = 1,4-phenylene, 1,3-xylylene, 4,4′-methylenebis(phenyl)] were initially designed and synthesized as potential ligands for the histamine H4 receptor (H4R). Considering the structural analogy of these thioureas to previously described seleno/thiourea compounds with anticancer and/or reversal multidrug resistance action in cancer cells, selected thioureas were evaluated in in-vitro cytotoxicity- and cancer multidrug resistance assays. The thiourea derivatives showed a good cytotoxic activity, being the compound II [R = 4-PhC6H4; X = S] the most active (IC50 = 11.9 μM). They also enhanced the cytotoxicity of the topoisomerase inhibitors topotecan and doxorubicin in a checkerboard combination assay. Compound I [R = 4-PhC6H4; X = S] showed the strongest synergistic effect on topotecan activity, whereas I [R = 4-MeC6H4; X = S] was the best in combination with doxorubicin. These results could be a good starting point to design more potent and effective (thio)urea derivatives with anticancer activity. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6HPLC of Formula: 16413-26-6).
3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. HPLC of Formula: 16413-26-6
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics