Preparation of some isothiocyanates was written by Cherbuliez, Emile;Weber, G.;Wyss, G.;Rabinowitz, J.. And the article was included in Helvetica Chimica Acta in 1965.Quality Control of 4-Fluorobenzylisothiocyanate This article mentions the following:
Isothiocyanates were prepared from amines and thiophosgene or by isomerization of benzyl thiocyanates. m-Trifluoromethylbenzonitrile and LiAlH4 in ether gave 73% m-trifluoromethylbenzylamine, b40 95-7°. Vigorously stirred CSCl2 in water treated with approx. an equimolar amount of RNH2 yielded the following RNCS (R, b.p., and % yield listed): m-F3CC6H4, b12 86-8°, 68; m-Fe3CC6H4CH2, b8 112-16°, 18; p-FC6H4(CH2)2, b12 135-9°, 27; p-O2NC6H4, -, 85; p-BrC6H4, -, 71; PhCH2, -, 60. p-Fluorobenzyl chloride and KSCN in Me2NCHO or Me2CO heated 4 hrs. at 40-60° gave 91% p-fluorobenzyl thiocyanate, b12 132-3°, which, heated 2 hrs. at 200°, yielded 70% p-fluorobenzyl isothiocyanate, b9 122-4°. p-Bromobenzyl bromide similarly gave 84% p-bromobenzyl thiocyanate, b12 172-5°, and 70% p-bromobenzyl isothiocyanate, b9 158-9°. 2-(p-Fluorophenyl)ethyl thiocyanate, b12 149-51°, obtained in 77% yield from the bromide, was not isomerized under these conditions. In the experiment, the researchers used many compounds, for example, 4-Fluorobenzylisothiocyanate (cas: 2740-88-7Quality Control of 4-Fluorobenzylisothiocyanate).
4-Fluorobenzylisothiocyanate (cas: 2740-88-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Quality Control of 4-Fluorobenzylisothiocyanate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics