Chang, Dong-Jo et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2009 | CAS: 180636-50-4

Methyl 4-fluoro-3-methylbenzoate (cas: 180636-50-4) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.COA of Formula: C9H9FO2

Design, synthesis and identification of novel colchicine-derived immunosuppressant was written by Chang, Dong-Jo;Yoon, Eun-Young;Lee, Geon-Bong;Kim, Soon-Ok;Kim, Wan-Joo;Kim, Young-Myeong;Jung, Jong-Wha;An, Hongchan;Suh, Young-Ger. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2009.COA of Formula: C9H9FO2 This article mentions the following:

Colchicine-derived nitrate esters I [R = MeO, SMe, Me2N; R1 = O2NO(CH2)3, 3-(O2NOCH2)C6H4, 4-(O2NOCH2)C6H4; R2 = H, Me] and II (R3, R4, R5 = H, MeO, F, Cl, Br, I, NC, O2N, Ph) are prepared as potential immunosuppressant agents and tested for their inhibition of the allogenic mixed-lymphocyte reaction. The cytotoxicities, inhibition of NO production, and inducible nitric oxide synthase and tumor necrosis factor-α levels for I [R = MeS; R1 = O2NO(CH2)3, 3-(O2NOCH2)C6H4] are determined; the inhibition of lymphoproliferation by I [R = MeS; R1 = O2NO(CH2)3, 3-(O2NOCH2)C6H4, 4-(O2NOCH2)C6H4; R2 = H] and by II (R3 = R4 = H; R5 = F), II (R3 = Cl; R4 = R5 = H), II (R3 = R4 = H; R5 = Cl), and II (R3 = O2N; R4 = R5 = H) are also determined The cytotoxicity of II (R3 = Cl; R4 = R5 = H) and its effectiveness in increasing skin allograft survival are determined and compared to that of cyclosporin A. In the experiment, the researchers used many compounds, for example, Methyl 4-fluoro-3-methylbenzoate (cas: 180636-50-4COA of Formula: C9H9FO2).

Methyl 4-fluoro-3-methylbenzoate (cas: 180636-50-4) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.COA of Formula: C9H9FO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics