Synthesis of substituted indole-3-carboxylates by iron(II)-catalyzed domino isomerization of 3-alkyl/aryl-4-aryl-5-methoxyisoxazoles was written by Bodunov, Vladimir A.;Galenko, Ekaterina E.;Galenko, Alexey V.;Novikov, Mikhail S.;Khlebnikov, Alexander F.. And the article was included in Synthesis in 2018.Category: esters-buliding-blocks This article mentions the following:
The iron(II)-catalyzed domino isomerization of 3-alkyl/aryl-4-arylisoxazoles provided a selective access to a wide range of structurally diverse highly substituted indole-3-carboxylates such as I [R = H, 6-Me, 4-MeO, etc.; R1 = Me, 4-ClC6H4, 2-naphthyl, etc.; R2 = Me, pyrrolidin-1-yl]. The operational simplicity, high atom efficiency and the use of stable starting materials and an inexpensive and low-toxicity catalyst were some of the attractive features of this tandem double ring-opening-ring-closure strategy. In the experiment, the researchers used many compounds, for example, Methyl 2-thienylacetate (cas: 19432-68-9Category: esters-buliding-blocks).
Methyl 2-thienylacetate (cas: 19432-68-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Category: esters-buliding-blocks
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics