Simultaneous analysis of volatile and semi-volatile components in a topical formulation by gas chromatography using a programmed temperature vaporization inlet and flame ionization detection was written by Anyakudo, Felix;Adams, Erwin;Van Schepdael, Ann. And the article was included in Journal of Pharmaceutical and Biomedical Analysis in 2019.SDS of cas: 118-61-6 This article mentions the following:
Topical formulations are medications applied locally on the skin to treat ailment. They are made up of complex mixtures of active ingredients and excipients. Till date, no anal. method has been found in literature that is able to simultaneously analyze volatile and semi-volatile actives present in topical formulations. In this work, an anal. procedure by gas chromatog. equipped with a programmed temperature vaporizing (PTV) inlet and a flame ionization detector was developed and validated for the simultaneous quant. determination of volatile and semi-volatile actives such as camphor, L-menthol, Me salicylate, Et salicylate, salicylic acid, glycol monosalicylate and capsaicin in a topical formulation. Liquid-liquid extraction was used to isolate the components of interest prior to injection into the gas chromatog. system. All target analytes were completely separated from each other and a linear calibration curve was achieved for all analytes with a determination coefficient > 0.995. 2-phenoxyethanol was used as internal standard for quantitation. Good repeatability and recovery values were achieved and reported. This method reports for the first time, the simultaneous quant. anal. of volatile and semi-volatile active pharmaceutical ingredients in a single measurement. The developed method was successfully applied to the anal. of real pharmaceutical samples and the described anal. protocols can be recommended for routine anal. of both volatile and semi-volatile actives in the topical formulation. In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxybenzoate (cas: 118-61-6SDS of cas: 118-61-6).
Ethyl 2-hydroxybenzoate (cas: 118-61-6) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. SDS of cas: 118-61-6
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics