Electrophilic fluorination with N,N’-difluoro-2,2′-bipyridinium salt and elemental fluorine was written by Adachi, Kenji;Ohira, Yutaka;Tomizawa, Ginjiro;Ishihara, Sumi;Oishi, Satoshi. And the article was included in Journal of Fluorine Chemistry in 2003.Name: Methyl 2-fluoro-3-oxopentanoate This article mentions the following:
N,N’-Difluoro-2,2′-bipyridinium bis(tetrafluoroborate) (MEC-31) was shown to be a highly reactive electrophilic fluorinating agent with the highest effective fluorine content in its class. We have developed the perfect recycled fluorination system with MEC-31 for the lower-cost industrial fluorination and for an environment. MEC-31 can be completely recycled including the counter-anion. We found the fluorination of 2-naphthol in liquid CO2 with MEC-31 in the presence of catalytic amount of NaOTf proceeded quant. without the generation of byproduct. In the fluorination of 1,3-dicarbonyl compounds with elemental fluorine, we found the introduction method of fluorine gas would be very important in order to make a reaction efficient. As fluorination goes on, the quantity of 1,3-dicarbonyl compounds of the starting material is reduced gradually, and therefore the quantity of fluorine must be reduced by the method to control the flow rate or the concentration of fluorine gas diluted with nitrogen, together the fluorination to proceed efficiently. In the experiment, the researchers used many compounds, for example, Methyl 2-fluoro-3-oxopentanoate (cas: 180287-02-9Name: Methyl 2-fluoro-3-oxopentanoate).
Methyl 2-fluoro-3-oxopentanoate (cas: 180287-02-9) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Name: Methyl 2-fluoro-3-oxopentanoate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics