Synthesis of Nine-Membered Carbocycles by the [4+3+2] Cycloaddition Reaction of Ethyl Cyclopropylideneacetate and Dienynes was written by Saito, Shinichi;Maeda, Kyotaro;Yamasaki, Ryu;Kitamura, Takuya;Nakagawa, Minami;Kato, Korehito;Azumaya, Isao;Masu, Hyuma. And the article was included in Angewandte Chemie, International Edition in 2010.Safety of Diethyl 2-(prop-2-yn-1-yl)malonate This article mentions the following:
In presence of [Ni(cod)2] and PPh3, [4+3+2] cycloaddition reactions of Et cyclopropylideneacetate and dienynes gave nine-membered carbocyclic compounds E.g., reaction of Et cyclopropylideneacetate and (E)-2-[2-methyl-2,4-pentadienyl]-2-(2-propynyl)malonic acid di-Et ester gave 57% bicyclic compound I. In the experiment, the researchers used many compounds, for example, Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9Safety of Diethyl 2-(prop-2-yn-1-yl)malonate).
Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Safety of Diethyl 2-(prop-2-yn-1-yl)malonate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics