Catalytic Enantioselective Synthesis of Highly Functionalized Difluoromethylated Cyclopropanes was written by Bos, Maxence;Huang, Wei-Sheng;Poisson, Thomas;Pannecoucke, Xavier;Charette, Andre B.;Jubault, Philippe. And the article was included in Angewandte Chemie, International Edition in 2017.Formula: C10H11FO2 This article mentions the following:
The first catalytic asym. synthesis of highly functionalized difluoromethylated cyclopropanes is described. The method, based on a rhodium-catalyzed cyclopropanation of difluoromethylated olefins, gives access to a broad range of cyclopropanes bearing ester, ketone, or nitro functional groups. By using Rh2((S)-BTPCP)4 as a catalyst, the corresponding products were obtained in high yields and high diastereo- and enantioselectivities (up 20:1 d.r. and 99 % ee). This methodol. allowed preparation of enantioenriched difluoromethylcyclopropanes for the first time. Thus, e.g., α-nitro diazo ketone I + α-(difluoromethyl)styrene → II (93%, 11.5:1 d.r., 99% ee) in presence of Rh2((S)-BTPCP)4 (III). In the experiment, the researchers used many compounds, for example, Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2Formula: C10H11FO2).
Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Formula: C10H11FO2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics