A Novel Minor Groove Binding Reagent Designed to Serve as a “Truck” To Carry DNA Modifying Moieties into the Major Groove was written by Xue, Tianhan;Browne, Kenneth A.;Bruice, Thomas C.. And the article was included in Bioconjugate Chemistry in 1995.Safety of Ethyl 4-nitro-1H-pyrrole-2-carboxylate This article mentions the following:
A site-selective DNA minor groove binding tripyrrole peptide has been synthesized as a “truck” to place chem. functionalities into the major groove which are capable of phys. modifying DNA, acting as catalysts to hydrolyze DNA, or effectively protecting DNA from various DNA modifying enzymes. The equilibrium dissociation constants for the binding of this peptide to an A3T3 dsDNA binding site have been determined to be nanomolar, and they are compared to the constants for other minor groove binding agents. In the experiment, the researchers used many compounds, for example, Ethyl 4-nitro-1H-pyrrole-2-carboxylate (cas: 5930-92-7Safety of Ethyl 4-nitro-1H-pyrrole-2-carboxylate).
Ethyl 4-nitro-1H-pyrrole-2-carboxylate (cas: 5930-92-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Safety of Ethyl 4-nitro-1H-pyrrole-2-carboxylate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics