Design and synthesis of a peptide that binds specific DNA sequences through simultaneous interaction in the major and minor groove was written by Vazquez, M. Eugenio;Caamano, Ana M.;Martinez-Costas, Jose;Castedo, Luis;Mascarenas, Jose L.. And the article was included in Angewandte Chemie, International Edition in 2001.Formula: C7H8N2O4 This article mentions the following:
A peptide derivative capable of binding to DNA with nanomolar affinity through a bivalent, major-minor groove recognition motif, was synthesized. Distamycin A, a well known tripyrrole antibiotic that binds DNA preferentially at A-T rich sites, was used for the minor groove and the basic region of GCN4, a bZIP protein which binds specifically to the cAMP response element site, for the major groove. A suitable linking of a b-ZIP basic region to a minor groove binding tripyrrole enabled for specific binding to its cognate DNA site. The hybrid compound revealed significantly higher affinity for its designated target DNA sequence than that of its isolated components for their resp. cognate subsites. In the experiment, the researchers used many compounds, for example, Ethyl 4-nitro-1H-pyrrole-2-carboxylate (cas: 5930-92-7Formula: C7H8N2O4).
Ethyl 4-nitro-1H-pyrrole-2-carboxylate (cas: 5930-92-7) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Formula: C7H8N2O4
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics