Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Antiproliferative and Antiinflammatory Activity was written by Travelli, Cristina;Aprile, Silvio;Rahimian, Reza;Grolla, Ambra A.;Rogati, Federica;Bertolotti, Mattia;Malagnino, Floriana;di Paola, Rosanna;Impellizzeri, Daniela;Fusco, Roberta;Mercalli, Valentina;Massarotti, Alberto;Stortini, Giorgio;Terrazzino, Salvatore;Del Grosso, Erika;Fakhfouri, Gohar;Troiani, Maria Pia;Alisi, Maria Alessandra;Grosa, Giorgio;Sorba, Giovanni;Canonico, Pier Luigi;Orsomando, Giuseppe;Cuzzocrea, Salvatore;Genazzani, Armando A.;Galli, Ubaldina;Tron, Gian Cesare. And the article was included in Journal of Medicinal Chemistry in 2017.Recommanded Product: Methyl 2-(4-(hydroxymethyl)phenyl)acetate This article mentions the following:
Nicotinamide phosphoribosyltransferase (NAMPT) is a key enzyme involved in the recycling of nicotinamide to maintain adequate NAD levels inside the cells. It has been postulated to be a pharmacol. target, as it is overexpressed in cancer cells as well as in inflammatory diseases. We describe the synthesis and characterization of a novel class of one-digit nanomolar NAMPT inhibitors based on in vitro characterization. The most active compound tested, I, displayed activity in xenograft and allograft models, strengthening the potential of NAMPT inhibitors as antitumoral drugs. Furthermore, in the present contribution we describe the ability of I to significantly improve the outcome of colitis in mice. Given that this is the first report of an effect of NAMPT inhibitors in colitis, this result paves the way for novel applications for this class of compounds In the experiment, the researchers used many compounds, for example, Methyl 2-(4-(hydroxymethyl)phenyl)acetate (cas: 155380-11-3Recommanded Product: Methyl 2-(4-(hydroxymethyl)phenyl)acetate).
Methyl 2-(4-(hydroxymethyl)phenyl)acetate (cas: 155380-11-3) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Recommanded Product: Methyl 2-(4-(hydroxymethyl)phenyl)acetate
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