Synthesis and Antileukemia Activity Evaluation of Benzophenanthridine Alkaloid Derivatives was written by Tang, Yaling;Xu, Xinglian;Li, Jiang;Deng, Lulu;Mu, Shuzhen. And the article was included in Molecules in 2022.Reference of 1190-39-2 This article mentions the following:
Thirty–three benzophenanthridine alkaloid derivatives (1a–1u and 2a–2l) were synthesized, and their cytotoxic activities against two leukemia cell lines (Jurkat Clone E6–1 and THP–1) were evaluated in vitro using a Cell Counting Kit–8 (CCK–8) assay. Nine of these derivatives (1i–l, 2a, and 2i–l) with IC50 values in the range of 0.18–7.94 μM showed significant inhibitory effects on the proliferation of both cancer cell lines. Anal. of the primary structure–activity relationships revealed that different substituent groups at the C–6 position might have an effect on the antileukemia activity of the corresponding compounds In addition, the groups at the C–7 and C–8 positions could influence the antileukemia activity. Among these compounds, 2j showed the strongest in vitro antiproliferative activity against Jurkat Clone E6–1 and THP–1 cells with good IC50 values (0.52 ± 0.03 μM and 0.48 ± 0.03 μM, resp.), slightly induced apoptosis, and arrested the cell-cycle, all of which suggests that compound 2j may represent a potentially useful start point to undergo further optimization toward a lead compound In the experiment, the researchers used many compounds, for example, malonic acid dibutyl ester (cas: 1190-39-2Reference of 1190-39-2).
malonic acid dibutyl ester (cas: 1190-39-2) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Reference of 1190-39-2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics